Elizabeth Trejos-Castillo, Ann Mastergeorge, Hugo Cogo-Moreira, Vinicius Oliveira Santana, André Zugman, Célia Maria de Araújo, Pedro Mario Pan, Felipe Picon, Luis Augusto Paim Rohde, Andrea P Jackowski
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Three years after baseline, the same participants underwent brain magnetic resonance imaging, and the Child Behaviour Checklist (CBCL) was administered. Automated segmentation of the amygdala and hippocampus was performed using FreeSurfer v.5.1 software.</p><p><strong>Results: </strong>Family conflict at baseline predicted internalising and externalising behaviours at follow-up. Evidence regarding the effects of family conflict and SES on brain structure and the moderating effects of family conflict on psychopathology and brain outcomes conditioned on SES was lacking.</p><p><strong>Conclusion: </strong>These results are consistent with emerging evidence that family conflict is a risk factor for externalising and internalising youth behaviour. These findings warrant further attention, focusing on prevention and intervention efforts and social policy development.</p>","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can Socioeconomic Status Moderate the Effect of a Conflictive Family Environment on Brain Structure and Externalising-Internalising Behaviour in Children and Adolescents?\",\"authors\":\"Elizabeth Trejos-Castillo, Ann Mastergeorge, Hugo Cogo-Moreira, Vinicius Oliveira Santana, André Zugman, Célia Maria de Araújo, Pedro Mario Pan, Felipe Picon, Luis Augusto Paim Rohde, Andrea P Jackowski\",\"doi\":\"10.47626/1516-4446-2025-4195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study examines the effects of socioeconomic status (SES) as a possible moderator of the effects of family conflict on externalising and internalising behaviours, and hippocampal and amygdala volumes.</p><p><strong>Methods: </strong>A longitudinal complete-case analysis of 714 children and adolescents (mean age: 11.2 years; 46.2% females) was conducted using data from the Brazilian High-Risk Cohort Study for Psychiatric Disorders in Childhood (BHRC). At baseline, parents/guardians completed the Family Environment Scale and the Brazilian SES Questionnaire. Three years after baseline, the same participants underwent brain magnetic resonance imaging, and the Child Behaviour Checklist (CBCL) was administered. Automated segmentation of the amygdala and hippocampus was performed using FreeSurfer v.5.1 software.</p><p><strong>Results: </strong>Family conflict at baseline predicted internalising and externalising behaviours at follow-up. Evidence regarding the effects of family conflict and SES on brain structure and the moderating effects of family conflict on psychopathology and brain outcomes conditioned on SES was lacking.</p><p><strong>Conclusion: </strong>These results are consistent with emerging evidence that family conflict is a risk factor for externalising and internalising youth behaviour. These findings warrant further attention, focusing on prevention and intervention efforts and social policy development.</p>\",\"PeriodicalId\":21244,\"journal\":{\"name\":\"Revista Brasileira de Psiquiatria\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Brasileira de Psiquiatria\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.47626/1516-4446-2025-4195\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira de Psiquiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47626/1516-4446-2025-4195","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Can Socioeconomic Status Moderate the Effect of a Conflictive Family Environment on Brain Structure and Externalising-Internalising Behaviour in Children and Adolescents?
Objective: This study examines the effects of socioeconomic status (SES) as a possible moderator of the effects of family conflict on externalising and internalising behaviours, and hippocampal and amygdala volumes.
Methods: A longitudinal complete-case analysis of 714 children and adolescents (mean age: 11.2 years; 46.2% females) was conducted using data from the Brazilian High-Risk Cohort Study for Psychiatric Disorders in Childhood (BHRC). At baseline, parents/guardians completed the Family Environment Scale and the Brazilian SES Questionnaire. Three years after baseline, the same participants underwent brain magnetic resonance imaging, and the Child Behaviour Checklist (CBCL) was administered. Automated segmentation of the amygdala and hippocampus was performed using FreeSurfer v.5.1 software.
Results: Family conflict at baseline predicted internalising and externalising behaviours at follow-up. Evidence regarding the effects of family conflict and SES on brain structure and the moderating effects of family conflict on psychopathology and brain outcomes conditioned on SES was lacking.
Conclusion: These results are consistent with emerging evidence that family conflict is a risk factor for externalising and internalising youth behaviour. These findings warrant further attention, focusing on prevention and intervention efforts and social policy development.
期刊介绍：
The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry).
The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.
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