Abdallah Al Said, Azhar Abdul Rahman, Fatin Nadhirah Binti A Halim, Laith Albadarneh, Ammar A Oglat, H H Saleh, Wesal Shloul, Yahya Alshloul
{"title":"在马来西亚建立成人全身PET/CT的当地诊断参考水平。","authors":"Abdallah Al Said, Azhar Abdul Rahman, Fatin Nadhirah Binti A Halim, Laith Albadarneh, Ammar A Oglat, H H Saleh, Wesal Shloul, Yahya Alshloul","doi":"10.1093/rpd/ncaf053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The combination of positron emission tomography (PET) and computed tomography (CT) scanning has significantly transformed the field of nuclear medicine.</p><p><strong>Purpose: </strong>This study aims to establish local diagnostic reference levels (LDRLs) for adult positron emission tomography/computed tomography (PET/CT) scans utilizing three radiotracers:18F-fluorodeoxyglucose (18F-FDG), 68Gallium-prostate-specific-membrane-antigen (68Ga-PSMA), and 68Gallium-etraazacyclododecane-tetraacetic-acid-octreotide (68Ga-DOTATATE).</p><p><strong>Methods: </strong>Demographic data, radiation dose information, scanner PET/CT system specifications, and acquisition protocols were collected from the Department of Nuclear Medicine at Penang Hospital in Malaysia. The LDRL was determined by calculating the 50th percentile.</p><p><strong>Results: </strong>The proposed LDRLs values for whole-body 18F-FDG, 68Ga-PSMA and 68Ga-DOTATATE scans were 264 MBq, 194.07 MBq, and 186.85 MBq, respectively. The proposed LDRL for the diagnostic CT parameters (CTDIvol and DLP) associated with whole-body 18F-FDG PET/CT scans were 4.04 mGy and 412.25 mGy.cm, while proposed LDRL values for 68Ga-PSMA and 68Ga-DOTATATE scans were 4.33 mGy and 452.16 mGy.cm, and 4.51 mGy and 468.69 mGy.cm, respectively.</p><p><strong>Conclusion: </strong>The administered activity of 18F-FDG, 68Ga-PSMA, and 68Ga-DOTATATE examinations can be reduced without compromising or affecting the image quality. The proposed LDRL values for the CT parameters of the whole-body 18F-FDG examinations were the lowest among all compared values, but 68Ga-PSMA and 68Ga-DOTATATE examinations require further studies to optimize patient radiation doses in Malaysia and other regions while maintaining image quality.</p>","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":" ","pages":"568-576"},"PeriodicalIF":0.8000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Establishing local diagnostic reference levels for adult whole-body PET/CT in Malaysia.\",\"authors\":\"Abdallah Al Said, Azhar Abdul Rahman, Fatin Nadhirah Binti A Halim, Laith Albadarneh, Ammar A Oglat, H H Saleh, Wesal Shloul, Yahya Alshloul\",\"doi\":\"10.1093/rpd/ncaf053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The combination of positron emission tomography (PET) and computed tomography (CT) scanning has significantly transformed the field of nuclear medicine.</p><p><strong>Purpose: </strong>This study aims to establish local diagnostic reference levels (LDRLs) for adult positron emission tomography/computed tomography (PET/CT) scans utilizing three radiotracers:18F-fluorodeoxyglucose (18F-FDG), 68Gallium-prostate-specific-membrane-antigen (68Ga-PSMA), and 68Gallium-etraazacyclododecane-tetraacetic-acid-octreotide (68Ga-DOTATATE).</p><p><strong>Methods: </strong>Demographic data, radiation dose information, scanner PET/CT system specifications, and acquisition protocols were collected from the Department of Nuclear Medicine at Penang Hospital in Malaysia. The LDRL was determined by calculating the 50th percentile.</p><p><strong>Results: </strong>The proposed LDRLs values for whole-body 18F-FDG, 68Ga-PSMA and 68Ga-DOTATATE scans were 264 MBq, 194.07 MBq, and 186.85 MBq, respectively. The proposed LDRL for the diagnostic CT parameters (CTDIvol and DLP) associated with whole-body 18F-FDG PET/CT scans were 4.04 mGy and 412.25 mGy.cm, while proposed LDRL values for 68Ga-PSMA and 68Ga-DOTATATE scans were 4.33 mGy and 452.16 mGy.cm, and 4.51 mGy and 468.69 mGy.cm, respectively.</p><p><strong>Conclusion: </strong>The administered activity of 18F-FDG, 68Ga-PSMA, and 68Ga-DOTATATE examinations can be reduced without compromising or affecting the image quality. The proposed LDRL values for the CT parameters of the whole-body 18F-FDG examinations were the lowest among all compared values, but 68Ga-PSMA and 68Ga-DOTATATE examinations require further studies to optimize patient radiation doses in Malaysia and other regions while maintaining image quality.</p>\",\"PeriodicalId\":20795,\"journal\":{\"name\":\"Radiation protection dosimetry\",\"volume\":\" \",\"pages\":\"568-576\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation protection dosimetry\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1093/rpd/ncaf053\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation protection dosimetry","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1093/rpd/ncaf053","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Establishing local diagnostic reference levels for adult whole-body PET/CT in Malaysia.
Background: The combination of positron emission tomography (PET) and computed tomography (CT) scanning has significantly transformed the field of nuclear medicine.
Purpose: This study aims to establish local diagnostic reference levels (LDRLs) for adult positron emission tomography/computed tomography (PET/CT) scans utilizing three radiotracers:18F-fluorodeoxyglucose (18F-FDG), 68Gallium-prostate-specific-membrane-antigen (68Ga-PSMA), and 68Gallium-etraazacyclododecane-tetraacetic-acid-octreotide (68Ga-DOTATATE).
Methods: Demographic data, radiation dose information, scanner PET/CT system specifications, and acquisition protocols were collected from the Department of Nuclear Medicine at Penang Hospital in Malaysia. The LDRL was determined by calculating the 50th percentile.
Results: The proposed LDRLs values for whole-body 18F-FDG, 68Ga-PSMA and 68Ga-DOTATATE scans were 264 MBq, 194.07 MBq, and 186.85 MBq, respectively. The proposed LDRL for the diagnostic CT parameters (CTDIvol and DLP) associated with whole-body 18F-FDG PET/CT scans were 4.04 mGy and 412.25 mGy.cm, while proposed LDRL values for 68Ga-PSMA and 68Ga-DOTATATE scans were 4.33 mGy and 452.16 mGy.cm, and 4.51 mGy and 468.69 mGy.cm, respectively.
Conclusion: The administered activity of 18F-FDG, 68Ga-PSMA, and 68Ga-DOTATATE examinations can be reduced without compromising or affecting the image quality. The proposed LDRL values for the CT parameters of the whole-body 18F-FDG examinations were the lowest among all compared values, but 68Ga-PSMA and 68Ga-DOTATATE examinations require further studies to optimize patient radiation doses in Malaysia and other regions while maintaining image quality.
期刊介绍：
Radiation Protection Dosimetry covers all aspects of personal and environmental dosimetry and monitoring, for both ionising and non-ionising radiations. This includes biological aspects, physical concepts, biophysical dosimetry, external and internal personal dosimetry and monitoring, environmental and workplace monitoring, accident dosimetry, and dosimetry related to the protection of patients. Particular emphasis is placed on papers covering the fundamentals of dosimetry; units, radiation quantities and conversion factors. Papers covering archaeological dating are included only if the fundamental measurement method or technique, such as thermoluminescence, has direct application to personal dosimetry measurements. Papers covering the dosimetric aspects of radon or other naturally occurring radioactive materials and low level radiation are included. Animal experiments and ecological sample measurements are not included unless there is a significant relevant content reason.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
