日本版LupusQoL的效度和信度:评估系统性红斑狼疮患者疾病特异性健康相关生活质量。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI:10.1177/09612033251344995
Sayuri Yamashita, Yasuhiro Katsumata, Sayumi Baba, Yuko Okamoto, Naoko Konda, Masayoshi Harigai
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引用次数: 0

摘要

目的研制日本版红斑狼疮质量评价量表(LupusQoL- jp),并评价其在系统性红斑狼疮(SLE)患者中的效度和可靠性。方法采用2011年(第一阶段,n = 266)和2015-2018年(第二阶段,n = 133)两个不同时期的数据进行独立横断面分析。英文版的LupusQoL被翻译成日文,并与其他问卷(包括医学结局研究短表-36 (SF-36)和5级EuroQoL 5-Dimensions问卷(EQ-5D-5L))一起给予日本SLE患者。医生还完成了系统性狼疮国际合作诊所/美国风湿病学会(ACR)损伤指数(SDI)和SLE疾病活动指数2000 (SLEDAI-2K)等测量,并评估了狼疮低疾病活动状态(LLDAS)的达到程度。结果slupusqol - jp具有良好的内部一致性(Cronbach's α > 0.8)。除疲劳外,所有量表均表现出良好的重测信度。LupusQoL-JP和SF-36得分与可比较域呈强相关。LupusQoL-JP分量表得分与EQ-5D-5L指数值呈中至强相关,与SDI呈弱相关,与年龄、病程、泼尼松龙剂量或SLEDAI-2K一般无相关性。一些LupusQoL-JP域能够区分LLDAS组和非LLDAS组。结论lupusqol - jp翻译、改编、验证成功。它与SF-36的相似域具有良好的并发效度,并且独立于SLEDAI-2K。根据LupusQoL-JP的评估,LLDAS的SLE患者与更好的疾病特异性健康相关生活质量部分相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validity and reliability of the Japanese version of LupusQoL: Assessment of disease-specific health-related quality of life in systemic lupus erythematosus.

ObjectiveTo develop a Japanese version of LupusQoL (LupusQoL-JP) and assess its validity and reliability in patients with systemic lupus erythematosus (SLE).MethodsThis study consisted of two independent cross-sectional analyses using data from two different periods at our university clinic: 2011 (initial period, n = 266) and 2015-2018 (second period, n = 133). The English version of the LupusQoL was translated into Japanese and administered to Japanese patients with SLE, alongside other questionnaires, including the Medical Outcomes Study Short Form-36 (SF-36) and the 5-level EuroQoL 5-Dimensions Questionnaire (EQ-5D-5L). Physicians also completed measures such as the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI) and SLE Disease Activity Index 2000 (SLEDAI-2K), and assessed lupus low disease activity state (LLDAS) attainment.ResultsLupusQoL-JP showed acceptable internal consistency (Cronbach's α > 0.8). All subscales, except for fatigue, demonstrated good test-retest reliability. The LupusQoL-JP and SF-36 scores were strongly correlated with comparable domains. The LupusQoL-JP subscale scores were moderately to strongly correlated with the EQ-5D-5L index values, while weakly correlated with the SDI and generally not correlated with age, disease duration, prednisolone dosage, or SLEDAI-2K. Some LupusQoL-JP domains were able to differentiate between the LLDAS and non-LLDAS groups.ConclusionLupusQoL-JP was successfully translated, adapted, and validated. It demonstrated good concurrent validity with comparable domains of the SF-36 and was independent of SLEDAI-2K. Patients with SLE in LLDAS were partly associated with better disease-specific health-related quality of life, as assessed by LupusQoL-JP.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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