{"title":"衰老过程中男性垂体细胞：免疫组织学和形态计量学研究。","authors":"Jovana Čukuranović-Kokoris, Braca Kundalić, Miljana Pavlović, Sladjana Ugrenović","doi":"10.5937/jomb0-54605","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aging is a multifactorial process, which inevitably leads to numerous changes in the life of each individual. As the lifespan of people around the world has increased, scientists began to study the mechanisms that would enable high-quality and safe aging. In this review, the focus is on showing the effect of aging on the characteristics of pituitary cells.</p><p><strong>Methods: </strong>In order to write this review, we undertook an electronic literature search through the PubMed and Google Scholar databases using the terms aging, histological, ultrastructure of pituitary cells, also using the \"related articles\" option. We also analyzed authored and co-authored articles, which were necessary for this type of publication.</p><p><strong>Results: </strong>This review article describes the immuno-histological, ultrastructural and morphometric characteristics of adrenocorticotropic (ACTH), somatotropic (GH), gonadotropic (LH) and folliculostellate (FS) pituitary cells during aging, in young (about 47 years) and old (over 70 years) human cadavers.</p><p><strong>Conclusions: </strong>The described immunohistological and morphometric characteristics of pituitary cells in this review showed that the volume density of ACTH, GH and LH cells was statistically increased (p<0.05) in old cadavers, which indicates an attempt by these cells to bring the pituitary gland to a relatively balanced state.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"203-210"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085187/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pituitary cells in man during aging: An immunohistological and morphometric study.\",\"authors\":\"Jovana Čukuranović-Kokoris, Braca Kundalić, Miljana Pavlović, Sladjana Ugrenović\",\"doi\":\"10.5937/jomb0-54605\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Aging is a multifactorial process, which inevitably leads to numerous changes in the life of each individual. As the lifespan of people around the world has increased, scientists began to study the mechanisms that would enable high-quality and safe aging. In this review, the focus is on showing the effect of aging on the characteristics of pituitary cells.</p><p><strong>Methods: </strong>In order to write this review, we undertook an electronic literature search through the PubMed and Google Scholar databases using the terms aging, histological, ultrastructure of pituitary cells, also using the \\\"related articles\\\" option. We also analyzed authored and co-authored articles, which were necessary for this type of publication.</p><p><strong>Results: </strong>This review article describes the immuno-histological, ultrastructural and morphometric characteristics of adrenocorticotropic (ACTH), somatotropic (GH), gonadotropic (LH) and folliculostellate (FS) pituitary cells during aging, in young (about 47 years) and old (over 70 years) human cadavers.</p><p><strong>Conclusions: </strong>The described immunohistological and morphometric characteristics of pituitary cells in this review showed that the volume density of ACTH, GH and LH cells was statistically increased (p<0.05) in old cadavers, which indicates an attempt by these cells to bring the pituitary gland to a relatively balanced state.</p>\",\"PeriodicalId\":16175,\"journal\":{\"name\":\"Journal of Medical Biochemistry\",\"volume\":\"44 2\",\"pages\":\"203-210\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085187/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5937/jomb0-54605\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5937/jomb0-54605","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Pituitary cells in man during aging: An immunohistological and morphometric study.
Background: Aging is a multifactorial process, which inevitably leads to numerous changes in the life of each individual. As the lifespan of people around the world has increased, scientists began to study the mechanisms that would enable high-quality and safe aging. In this review, the focus is on showing the effect of aging on the characteristics of pituitary cells.
Methods: In order to write this review, we undertook an electronic literature search through the PubMed and Google Scholar databases using the terms aging, histological, ultrastructure of pituitary cells, also using the "related articles" option. We also analyzed authored and co-authored articles, which were necessary for this type of publication.
Results: This review article describes the immuno-histological, ultrastructural and morphometric characteristics of adrenocorticotropic (ACTH), somatotropic (GH), gonadotropic (LH) and folliculostellate (FS) pituitary cells during aging, in young (about 47 years) and old (over 70 years) human cadavers.
Conclusions: The described immunohistological and morphometric characteristics of pituitary cells in this review showed that the volume density of ACTH, GH and LH cells was statistically increased (p<0.05) in old cadavers, which indicates an attempt by these cells to bring the pituitary gland to a relatively balanced state.
期刊介绍：
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
The Journal publishes original scientific and specialized articles on all aspects of
clinical and medical biochemistry,
molecular medicine,
clinical hematology and coagulation,
clinical immunology and autoimmunity,
clinical microbiology,
virology,
clinical genomics and molecular biology,
genetic epidemiology,
drug measurement,
evaluation of diagnostic markers,
new reagents and laboratory equipment,
reference materials and methods,
reference values,
laboratory organization,
automation,
quality control,
clinical metrology,
all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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