Wen Qiu, Yong K Yan, Jian P Kang, Jie Yang, Wei Li
{"title":"骨髓增生异常综合征的检测挑战：有核红细胞漏检一例报告。","authors":"Wen Qiu, Yong K Yan, Jian P Kang, Jie Yang, Wei Li","doi":"10.7754/Clin.Lab.2024.241106","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nucleated red blood cells (NRBCs) play a crucial role in automated blood analysis, particularly in the diagnosis and monitoring of blood disorders. This study examines the limitations of the Sysmex XN-9000 fully automated modular hematology analyzer in detecting nucleated red blood cells (NRBCs) in patients with myelodysplastic syndromes (MDS).</p><p><strong>Methods: </strong>Peripheral blood samples from a patient diagnosed with MDS were analyzed using the XN-9000 analyzer. Manual digital microscopy was employed for validation and detailed cell counts.</p><p><strong>Results: </strong>The XN-9000 incorrectly identified nucleated erythrocytes as monocytes and failed to detect an abnormal quantity of NRBCs. Manual review revealed a significantly lower white blood cell count compared to the automated count, and a notable increase in NRBCs alongside a decrease in monocyte percentage.</p><p><strong>Conclusions: </strong>Fully automated hematology analyzers may have limitations in detecting certain hematopathological conditions, and manual microscopy is essential to ensure diagnostic completeness and accuracy.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Detection Challenges in Myelodysplastic Syndromes: a Case Report of Missed Detection of Nucleated Red Blood Cells.\",\"authors\":\"Wen Qiu, Yong K Yan, Jian P Kang, Jie Yang, Wei Li\",\"doi\":\"10.7754/Clin.Lab.2024.241106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nucleated red blood cells (NRBCs) play a crucial role in automated blood analysis, particularly in the diagnosis and monitoring of blood disorders. This study examines the limitations of the Sysmex XN-9000 fully automated modular hematology analyzer in detecting nucleated red blood cells (NRBCs) in patients with myelodysplastic syndromes (MDS).</p><p><strong>Methods: </strong>Peripheral blood samples from a patient diagnosed with MDS were analyzed using the XN-9000 analyzer. Manual digital microscopy was employed for validation and detailed cell counts.</p><p><strong>Results: </strong>The XN-9000 incorrectly identified nucleated erythrocytes as monocytes and failed to detect an abnormal quantity of NRBCs. Manual review revealed a significantly lower white blood cell count compared to the automated count, and a notable increase in NRBCs alongside a decrease in monocyte percentage.</p><p><strong>Conclusions: </strong>Fully automated hematology analyzers may have limitations in detecting certain hematopathological conditions, and manual microscopy is essential to ensure diagnostic completeness and accuracy.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 5\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2024.241106\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.241106","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Detection Challenges in Myelodysplastic Syndromes: a Case Report of Missed Detection of Nucleated Red Blood Cells.
Background: Nucleated red blood cells (NRBCs) play a crucial role in automated blood analysis, particularly in the diagnosis and monitoring of blood disorders. This study examines the limitations of the Sysmex XN-9000 fully automated modular hematology analyzer in detecting nucleated red blood cells (NRBCs) in patients with myelodysplastic syndromes (MDS).
Methods: Peripheral blood samples from a patient diagnosed with MDS were analyzed using the XN-9000 analyzer. Manual digital microscopy was employed for validation and detailed cell counts.
Results: The XN-9000 incorrectly identified nucleated erythrocytes as monocytes and failed to detect an abnormal quantity of NRBCs. Manual review revealed a significantly lower white blood cell count compared to the automated count, and a notable increase in NRBCs alongside a decrease in monocyte percentage.
Conclusions: Fully automated hematology analyzers may have limitations in detecting certain hematopathological conditions, and manual microscopy is essential to ensure diagnostic completeness and accuracy.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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