靶向组蛋白H3K9甲基转移酶G9a作为神经精神疾病的潜在治疗策略

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek
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引用次数: 0

摘要

神经精神疾病呈现出多方面的挑战,其特点是认知、社会和运动障碍具有多种潜在机制。最近的研究转向表观遗传机制,特别是组蛋白赖氨酸甲基转移酶(HKMTs),如G9a,以了解其基本发病机制。本文综述了G9a的结构和功能特征及其在神经精神疾病中的作用,包括神经发育障碍(ndd),如自闭症谱系障碍(ASD)和Prader-Willi综合征(PWS)、精神分裂症(SZ)、癫痫、焦虑、抑郁和阿尔茨海默病(AD)。此外,它强调了G9a介导的组蛋白甲基化的生化机制,并探索了针对G9a的潜在治疗途径的药物干预。目前的知识强调了G9a作为治疗靶点的重要性,并为未来研究其在神经精神疾病中的作用奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders.

Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis. This review provides a concise overview of the structural and functional features of G9a and its involvement in neuropsychiatric disorders, including neurodevelopmental disorders (NDDs) like autism spectrum disorders (ASD) and Prader-Willi syndrome (PWS), schizophrenia (SZ), epilepsy, anxiety, depression, and Alzheimer's disease (AD). Furthermore, it highlights the biochemical mechanisms of G9a-mediated histone methylations and explores pharmacological interventions targeting G9a for potential therapeutic avenues. This current knowledge underlines G9a's significance as a therapeutic target and sets the stage for future investigations into its role in neuropsychiatric disorders.

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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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