通过芳构化驱动的解构策略，双镍/光氧化还原催化螺-二氢喹唑啉酮与羧酸的酰化。

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-05-19 DOI:10.1039/d5cc01289a

Wen-Chao Gao, Yong Teng, Jie Yang, Wen-Dian Li, Wen-Guang Li, Ke-Xin Huang, Ting Li

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引用次数: 0

摘要

描述了双镍/光氧化还原催化芳香化介导的螺-二氢喹唑啉酮的羧酸作为酰基亲电试剂的解构和酰化。在温和的条件下可获得一系列具有官能团耐受性的合成酮类支架。对于这些转化，提出了一个涉及n中心自由基诱导β-断裂形成c中心自由基的自由基途径。

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Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids via an aromatization-driven deconstructive strategy.

Dual-nickel/photoredox-catalyzed aromatization-mediated deconstruction and acylation of spiro-dihydroquinazolinones with carboxylic acids serving as acyl electrophiles is described. A series of synthetical ketone scaffolds with functional group tolerance could be obtained under mild conditions. A radical pathway involving an N-centered radical inducing β-scission to form a C-centered radical is proposed for these transformations.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.