Ángel Oliva-Pascual-Vaca, Ignacio Navarro-Carmona, Jesús Oliva-Pascual-Vaca, Inmaculada Riquelme, Luis Gabriel Luque-Romero, José Manuel López-Millán
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The date of publication was not limited. References from included articles were assessed. The sample, experimental intervention, and the results were retrieved from each study.</p>\n <p><b>Results:</b> Sixteen studies were included. Acromiotrapezius muscle showed the highest activity to gastric damage, being up to 8–10 times higher than abdominal muscles contraction. Also, a postural response compatible with neck muscles spasm was observed. The threshold for reaching cervical spasm was lowered by the addition of stress, gastritis, dyspepsia, ulcers, diabetes, or inflammation of the colon. Increased visceromotor response persisted even more than 60 days after gastric insult, despite no obvious injury was already visible in the stomach. Furthermore, prenatal or neonatal gastric injury also produced gastric hypersensitivity and increased trapezius spasm in adult rats. On the contrary, neck spasm was reduced by reversing diabetes or blocking the gastric receptors and its afferent pathways.</p>\n <p><b>Conclusions:</b> Gastric harm triggers neck muscles spasm. Since many gastric conditions and hypersensitivity are common and tend to be chronic, this may contribute to explain the persistence of neck pain and sensitization in many patients. Prenatal and neonatal gastrointestinal suffering increases trapezius visceromotor response in adults. 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引用次数: 0
摘要
背景：大多数颈部疼痛病例被归类为非特异性或特发性疼痛，并表现出敏感性、痛觉过敏、活动范围受限和肌肉痉挛等特征。内脏疾病会引发所有这些症状，而胃部疾病与颈部疼痛有关。此外，压力和焦虑经常被躯体化为颈部疼痛。然而，其病理生理联系尚未确定。目的：探讨实验性胃损伤大鼠的肌电图和体位反应。方法：进行系统评价。在PubMed和Web of Science数据库中进行了搜索。出版日期不受限制。评估纳入文献的参考文献。从每项研究中检索样本、实验干预和结果。结果：纳入16项研究。肩斜方肌对胃损伤的活性最高，为腹肌收缩的8-10倍。此外，观察到与颈部肌肉痉挛相适应的姿势反应。由于压力、胃炎、消化不良、溃疡、糖尿病或结肠炎症的增加，达到颈椎痉挛的门槛降低。尽管胃内未见明显损伤，但内脏运动反应的增强在胃损伤后仍持续超过60天。此外，产前或新生儿胃损伤也会导致成年大鼠胃过敏和斜方肌痉挛增加。相反，通过逆转糖尿病或阻断胃受体及其传入通路，颈部痉挛减少。结论：胃损伤引起颈部肌肉痉挛。由于许多胃病和超敏反应是常见的，而且往往是慢性的，这可能有助于解释许多患者持续存在颈部疼痛和致敏反应。产前和新生儿胃肠疾患增加成人斜方肌内脏运动反应。此外，我们的发现可能有助于解释为什么压力经常被躯体化为颈部疼痛。
Idiopathic Neck Pain or Neck Pain of Gastric Origin? A Systematic Review of Rat Experimental Studies on Gastric Harm Pathophysiology and Therapy
Background: Most cases of neck pain are classified as nonspecific or idiopathic pain and show characteristics such as sensitization, hyperalgesia, limited range of motion, and muscle spasm. Visceral disorders can trigger all those features, and gastric disorders are related to neck pain. Furthermore, stress and anxiety are frequently somaticized as neck pain. However, its pathophysiological link has never been determined.
Objectives: To identify the electromyographic and postural response to experimental gastric insult in rats.
Methods: A systematic review was undertaken. Searches were conducted in the PubMed and Web of Science databases. The date of publication was not limited. References from included articles were assessed. The sample, experimental intervention, and the results were retrieved from each study.
Results: Sixteen studies were included. Acromiotrapezius muscle showed the highest activity to gastric damage, being up to 8–10 times higher than abdominal muscles contraction. Also, a postural response compatible with neck muscles spasm was observed. The threshold for reaching cervical spasm was lowered by the addition of stress, gastritis, dyspepsia, ulcers, diabetes, or inflammation of the colon. Increased visceromotor response persisted even more than 60 days after gastric insult, despite no obvious injury was already visible in the stomach. Furthermore, prenatal or neonatal gastric injury also produced gastric hypersensitivity and increased trapezius spasm in adult rats. On the contrary, neck spasm was reduced by reversing diabetes or blocking the gastric receptors and its afferent pathways.
Conclusions: Gastric harm triggers neck muscles spasm. Since many gastric conditions and hypersensitivity are common and tend to be chronic, this may contribute to explain the persistence of neck pain and sensitization in many patients. Prenatal and neonatal gastrointestinal suffering increases trapezius visceromotor response in adults. Furthermore, our findings might contribute to explain why stress is frequently somaticized as neck pain.
期刊介绍：
IJCP is a general medical journal. IJCP gives special priority to work that has international appeal.
IJCP publishes:
Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion]
Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion]
Study design and interpretation. Example. [Always peer reviewed]
Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed]
Meta-analyses. [Always peer reviewed]
Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed]
Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed]
''How to…'' papers. Example. [Always peer reviewed]
Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed]
Letters. [Peer reviewed at the editor''s discretion]
International scope
IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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