全面了解壳聚糖水凝胶:从交联和表征到免疫调节,微生物组相互作用和生物医学用途

IF 3.5 4区 工程技术 Q3 ENERGY & FUELS
Sarika Torgal, Gomathi Subramani, Rameshpathy Manian
{"title":"全面了解壳聚糖水凝胶:从交联和表征到免疫调节,微生物组相互作用和生物医学用途","authors":"Sarika Torgal,&nbsp;Gomathi Subramani,&nbsp;Rameshpathy Manian","doi":"10.1007/s13399-024-06350-2","DOIUrl":null,"url":null,"abstract":"<div><p>Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":488,"journal":{"name":"Biomass Conversion and Biorefinery","volume":"15 9","pages":"13191 - 13226"},"PeriodicalIF":3.5000,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comprehensive insights into chitosan hydrogels: from crosslinking and characterization to immunomodulation, microbiome interactions and biomedical uses\",\"authors\":\"Sarika Torgal,&nbsp;Gomathi Subramani,&nbsp;Rameshpathy Manian\",\"doi\":\"10.1007/s13399-024-06350-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":488,\"journal\":{\"name\":\"Biomass Conversion and Biorefinery\",\"volume\":\"15 9\",\"pages\":\"13191 - 13226\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomass Conversion and Biorefinery\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13399-024-06350-2\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENERGY & FUELS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomass Conversion and Biorefinery","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13399-024-06350-2","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENERGY & FUELS","Score":null,"Total":0}
引用次数: 0

摘要

由于对替代生物材料,特别是水凝胶和壳聚糖基水凝胶的探索,对生物医学领域的兴趣激增。这些材料具有独特的特性,如与生物系统的相容性、在生物环境中的自然分解和经济效率,使它们具有非常有前途的多种应用。壳聚糖,无论是以其纯形式还是与其他聚合物结合,由于其在生物医学应用中的潜力,已经成为一个关键的焦点。其免疫调节特性特别值得注意,因为它们有助于调节免疫反应,这有利于组织工程和药物输送目的。壳聚糖的生物可降解性确保了应用后的环保降解,解决了对长期影响的担忧。此外,它与微生物组的相互作用有望促进与微生物群落的共生关系,这对于维持生物环境中的稳态至关重要。本文综述了壳聚糖水凝胶制备、壳聚糖改性的各种表征方法和交联技术,并探讨了其在免疫调节、生物降解性和微生物相互作用方面的医学应用和意义。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive insights into chitosan hydrogels: from crosslinking and characterization to immunomodulation, microbiome interactions and biomedical uses

Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.

Graphical Abstract

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biomass Conversion and Biorefinery
Biomass Conversion and Biorefinery Energy-Renewable Energy, Sustainability and the Environment
CiteScore
7.00
自引率
15.00%
发文量
1358
期刊介绍: Biomass Conversion and Biorefinery presents articles and information on research, development and applications in thermo-chemical conversion; physico-chemical conversion and bio-chemical conversion, including all necessary steps for the provision and preparation of the biomass as well as all possible downstream processing steps for the environmentally sound and economically viable provision of energy and chemical products.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信