{"title":"全面了解壳聚糖水凝胶:从交联和表征到免疫调节,微生物组相互作用和生物医学用途","authors":"Sarika Torgal, Gomathi Subramani, Rameshpathy Manian","doi":"10.1007/s13399-024-06350-2","DOIUrl":null,"url":null,"abstract":"<div><p>Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":488,"journal":{"name":"Biomass Conversion and Biorefinery","volume":"15 9","pages":"13191 - 13226"},"PeriodicalIF":3.5000,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comprehensive insights into chitosan hydrogels: from crosslinking and characterization to immunomodulation, microbiome interactions and biomedical uses\",\"authors\":\"Sarika Torgal, Gomathi Subramani, Rameshpathy Manian\",\"doi\":\"10.1007/s13399-024-06350-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":488,\"journal\":{\"name\":\"Biomass Conversion and Biorefinery\",\"volume\":\"15 9\",\"pages\":\"13191 - 13226\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomass Conversion and Biorefinery\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13399-024-06350-2\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENERGY & FUELS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomass Conversion and Biorefinery","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13399-024-06350-2","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENERGY & FUELS","Score":null,"Total":0}
Comprehensive insights into chitosan hydrogels: from crosslinking and characterization to immunomodulation, microbiome interactions and biomedical uses
Interest in the biomedical field has surged due to the exploration of alternative biomaterials, particularly hydrogels and chitosan-based hydrogels. These materials present distinctive attributes such as compatibility with living systems, natural breakdown in biological environments, and economic efficiency, rendering them highly promising diverse applications. Chitosan, whether in its pure form or in combination with other polymers, has emerged as a key focus due to its potential in biomedical applications. Its immunomodulatory properties are particularly noteworthy, as they contribute to regulating immune responses, which is beneficial for tissue engineering and drug delivery purposes. Chitosan’s biodegradability ensures environmentally friendly degradation post-application, addressing concerns about long-term impact. Additionally, its interaction with the microbiome holds promise for promoting symbiotic relationships with microbial communities, crucial for maintaining homeostasis in biological environments. This comprehensive review delves into the diverse characterization methods and crosslinking techniques utilized in crafting chitosan hydrogels, modification of chitosan while also exploring their medical applications and implications in immunomodulation, biodegradability, and microbiome interaction.
期刊介绍:
Biomass Conversion and Biorefinery presents articles and information on research, development and applications in thermo-chemical conversion; physico-chemical conversion and bio-chemical conversion, including all necessary steps for the provision and preparation of the biomass as well as all possible downstream processing steps for the environmentally sound and economically viable provision of energy and chemical products.