Cu/Rh接力催化合成四取代糠醇

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-17 DOI:10.1016/j.tetlet.2025.155661

Qinglong Liu , Chen Qu , Yubin Zheng , Wangze Song

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引用次数: 0

摘要

实现四取代糠醇的直接合成是一个挑战。本研究公开了以吡啶- n -氧化物为氧源，采用Cu/Rh继电器催化制备1,3-二羰基化合物和丙炔酯的四取代糠醇的一锅法。该方法在温和的反应条件下可有效地形成1个CC键和2个CO键，为制备四取代糠醇提供了一条实用的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of tetra-substituted Furfuryl alcohols by Cu/Rh relay catalysis

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Synthesis of tetra-substituted Furfuryl alcohols by Cu/Rh relay catalysis

It is a challenge to achieve the direct synthesis of tetra-substituted furfuryl alcohols. Herein, we disclosed a one-pot method for the preparation of tetra-substituted furfuryl alcohols with 1,3-dicarbonyl compounds and propargyl esters by Cu/Rh relay catalysis using pyridine-N-oxide as the oxygen source. One CC bond and two CO bonds could be efficiently formed by this approach with mild reaction conditions, which provides a practical approach to access tetra-substituted furfuryl alcohols.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.