金属有机骨架强化肺癌治疗

IF 4.8 3区 材料科学 Q1 CHEMISTRY, APPLIED
Kornelia Hyjek , Klaudia Dymek , Grzegorz Kurowski , Anna Boguszewska-Czubara , Sylwia Wnorowska , Anna Pajdak , Łukasz Kuterasiński , Witold Piskorz , Anna Gancarczyk , Marzena Iwaniszyn , Arturo Cubi , Maryna Khalavka , Przemysław J. Jodłowski
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引用次数: 0

摘要

这项研究证明了锆基金属有机骨架作为肺癌治疗的缓释化疗药物载体的潜在用途。比较5-氟尿嘧啶(5-FU)与α-氰基-4-羟基肉桂酸(α-CHC)的治疗效果。UiO-66模型组通过改变缺陷数量和增加氨基的存在,检测其5-FU和α-CHC@UiO-66复合材料。通过干粉吸入器评估其给药性能。研究了制备的复合材料在不同介质中的药物释放动力学,包括SBF和SLF流体。观察了离子环境、氨基在MOF结构表面的存在以及引入分子向质子化的趋势的影响。DFT模型证实了吸附机理,表明-NH2基团对吸附能量学有深远的影响。对于UiO-66,分子中芳香环与MOF连接体的相互取向表明存在π-π堆积。吸附物分子和MOF框架之间积累的共价键顺序也支持吸附的性质。体外和体内研究都强调了该疗法的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancing lung cancer treatment with metal–organic frameworks
This study demonstrates the potential use of Zr-based metal–organic frameworks as carriers of gradual-release chemotherapeutics for lung cancer therapy. The therapeutic efficacy of 5-fluorouracil (5-FU) was compared to that of α-cyano-4-hydroxycinnamic acid (α-CHC). The model group of UiO-66 varied the number of defects and the presence of additional amino groups, and their 5-FU and α-CHC@UiO-66 composites were examined. Their performance in drug delivery was evaluated through dry powder inhalers. The drug release kinetics from prepared composites were studied in different media, including SBF and SLF fluids. The effects of the ionic environment, the presence of an amino group on the surface of the MOF structure, and the tendency of the introduced molecule to protonate were observed. The sorption mechanisms were corroborated with DFT modeling, showing the profound impact of the –NH2 groups on the adsorption energetics. For UiO-66, the mutual orientation of the aromatic rings in the molecule and the MOF linker indicate the presence of the π-π stacking. The accumulated covalent bond order between the adsorbate molecule and the MOF framework also supports the nature of the adsorption. The in vitro and in vivo studies emphasize both the safety and efficacy of the presented therapy.
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来源期刊
Microporous and Mesoporous Materials
Microporous and Mesoporous Materials 化学-材料科学:综合
CiteScore
10.70
自引率
5.80%
发文量
649
审稿时长
26 days
期刊介绍: Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.
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