鼻甲射频消融后雾化透明质酸和木糖醇基溶液。一项三盲随机多中心临床试验

IF 0.9 Q3 OTORHINOLARYNGOLOGY

Acta otorrinolaringologica espanola Pub Date : 2025-05-01 DOI:10.1016/j.otorri.2025.512218

Christian Calvo-Henríquez , Ainhoa García-Lliberos , Byron Maldonado-Alvarado , Miguel Rodriguez-Iglesias , David Lobo-Duro , Juan Maza-Solano , Serafín Sánchez-Gomez , Isam Alobid

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引用次数: 0

摘要

目的：本前瞻性、三盲随机临床试验旨在专门评估Aluneb®（透明质酸加西利醇）在成人下鼻甲术后射频治疗中的效果，并与雾化等渗盐水进行比较。方法选取接受射频鼻甲消融的成人为研究对象。治疗组给予Aluneb®（透明质酸加木糖醇）治疗，对照组给予等渗生理盐水雾化治疗2个月。参与者在手术前一周（第0次访问）以及手术后7、15、30和60天进行研究。在所有访问中，参与者接受体格检查、鼻测压、SNOT-22和症状视觉模拟量表（VAS）。结果共招募34名受试者。Aluneb®透明质酸加木糖醇组结痂（内窥镜检查）较少。鼻结皮、鼻出血、鼻塞VAS均有统计学意义。透明质酸加西利醇组鼻臭、口臭、鼻臭、疼痛和鼻阻力VAS自述值较低，但差异无统计学意义。结论透明质酸加西利醇可改善术后预后，值得进一步开展更大样本量和不同手术技术的研究。

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Nebulized hyaluronic acid and xylitol based solution after turbinate radiofrequency ablation. A triple blind randomized multicentric clinical trial

Objective

This prospective, triple blind randomized clinical trial aims to specifically evaluate the effect of Aluneb® (hyaluronic acid plus xilitol) in the postoperative treatment of inferior turbinate radiofrequency in adults compared to nebulized isotonic saline.

Methods

Adults undergoing radiofrequency turbinate ablation were included. Treatment group received Aluneb® (hyaluronic acid plus xylitol) while the control group received nebulized isotonic saline for two months after treatment. Participants were studied the week before surgery (visit 0), and at 7, 15, 30 and 60 days after surgery. At all visits, participants underwent physical examination, rhinomanometry, SNOT-22, and visual analogue scale (VAS) of symptoms.

Results

34 participants were recruited. Crusts (endoscopy) were less in the Aluneb® hyaluronic acid plus xylitol group. Nasal crusting, epistaxis and nasal obstruction VAS were statistically significant lower. VAS for Rhinorrea, halitosis, cacosmia and pain and nasal resistance obtained lower self-reported values in the hyaluronic acid plus xilitol group, but these differences were not statistically significant.

Conclusions

Hyaluronic acid plus xilitol demonstrated promise in improving postoperative outcomes, future studies with larger sample sizes and different surgical techniques are encouraged.

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来源期刊

Acta otorrinolaringologica espanola OTORHINOLARYNGOLOGY-

CiteScore

1.40

自引率

20.00%

发文量

审稿时长

44 days

期刊介绍： Es la revista más importante en español dedicada a la especialidad. Ofrece progresos científicos y técnicos tanto a nivel de originales como de casos clínicos. Además, es la Publicación Oficial de la Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial y está presente en los más prestigiosos índices de referencia.