可见光光氧化还原催化非活化烯烃氢膦化反应

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-05-14 DOI:10.1016/j.tet.2025.134712

Ming Qi, An-Wu Xu

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引用次数: 0

摘要

我们报道了一种低浓度光催化剂（4CzIPN）催化的非活化烯烃的可见光诱导氢膦化反应，提供了一种简单、高效和环保的构建C-P键的方法。该方法具有广泛的衬底范围和综合有效产率，并通过克级实验进一步证明了其实用性。通过详细的实验研究和理论计算，阐明了其机理。通过对线型烯烃和功能化烯烃的比较，我们对自由基反应过程有了更深入的了解，这对叔膦氧化物的合成策略的发展是有益的。

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Visible light photoredox catalyzed hydrophosphinylation of unactivated alkenes

We report a visible light-induced hydrophosphinylation of unactivated alkenes catalyzed by a low-concentration photocatalyst (4CzIPN), affording a simple, efficient and environmentally friendly method for constructing C–P bonds. This method exhibits a broad substrate scope and synthetically useful yields, and its practicability is further demonstrated by gram-scale experiments. The mechanism was elucidated through detailed experimental studies and theoretical calculations. By comparing linear alkenes with functionalized alkenes, we gained insights into the radical process, which is beneficial for the development of synthetic strategies for tertiary phosphine oxides.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.