评估海藻酸盐敷料在烧伤创面和供区创面处理中的治疗效果和安全性:当代随机对照试验的系统回顾和荟萃分析。

IF 1.6 3区 医学 Q2 SURGERY
Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jingyao Song, Neng Huang, Jiliang Li, Guoying Jin, Shengyong Cui, Pei Xu, Xin Le, Youfen Fan, Sida Xu
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引用次数: 0

摘要

背景:海藻酸盐基敷料因其吸收和愈合的特性而广泛应用于烧伤护理;然而,临床结果仍然不一致。方法:本研究遵循PRISMA指南,我们系统地检索了PubMed、Embase、Cochrane和Web of Science的随机对照试验(rct),比较海藻酸盐敷料与烧伤患者及其供体部位的其他治疗方法。纳入标准侧重于具有可测量结果的前瞻性试验,如愈合时间、疼痛评分、换药频率和不良事件。采用标准化方法进行数据提取和质量评估,采用r4.4.2和Stata 15.0进行meta分析,采用GRADE方法评估证据确定性。将数据汇总并报告为相对危险度(RR)、平均差(MD)和标准化平均差(SMD),置信区间为95%。结果:15项研究符合纳入标准。荟萃分析显示,与对照组相比,海藻酸盐敷料的愈合时间显著缩短,MD为-1.09天(95% CI: -1.67至-0.31,p 2 = 94.6%)。疼痛评分也倾向于海藻酸盐敷料,SMD为-1.37 (95% CI: -2.53至-0.21,p = 0.000, I2 = 90.9%)。换药频率无显著差异,SMD为2.18 (95% CI: -4.29 ~ -0.07, p = 0.000, I2 = 94.0%)。不良事件的RR为0.81 (95% CI: 0.50 ~ 1.30, p = 0.021, I2 = 51.1%),表明两组患者的安全性相似。结论:我们的研究结果表明海藻酸盐敷料不仅显著缩短愈合时间,而且具有临床相关的益处,包括减轻疼痛和减少敷料更换,使其成为烧伤创面管理的宝贵选择。然而,它们对换药频率和不良事件的影响仍然与对照治疗相当。尽管方法学的局限性,如高异质性和潜在的偏差,海藻酸盐敷料在临床环境中保持优势。为了提高对海藻酸盐敷料在不同烧伤创面和供区创面护理中的认识和应用,有必要制定标准化的评价标准和长期研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the therapeutic efficacy and safety of alginate-based dressings in burn wound and donor site wound management associated with burn surgery: a systematic review and meta-analysis of contemporary randomized controlled trials.

Background: Alginate-based dressings are widely used in burn care for their absorptive and healing properties; however, inconsistencies in clinical outcomes remain.

Methods: This study followed the PRISMA guidelines, we systematically searched PubMed, Embase, Cochrane, and Web of Science for randomized controlled trials (RCTs) comparing alginate dressings to other treatments in burn patients and their donor sites. Inclusion criteria focused on prospective trials with measured outcomes such as healing time, pain scores, dressing change frequency, and adverse events. Data extraction and quality assessment adhered to standardized methods, and meta-analyses were performed using R 4.4.2 and Stata 15.0 with the GRADE approach to evaluate evidence certainty. Data were aggregated and reported as relative risk (RR), mean difference (MD) and standardized mean difference (SMD), with a 95% confidence interval (CI).

Results: Fifteen studies met the inclusion criteria. The meta-analysis revealed a significantly shorter healing time with alginate dressings versus controls, showing a MD of -1.09 days (95% CI: -1.67 to -0.31, p < 0.001, I2 = 94.6%). Pain scores also favored alginate dressings, with a SMD of -1.37 (95% CI: -2.53 to -0.21, p = 0.000, I2 = 90.9%). There was no significant difference in dressing change frequency, with an SMD of 2.18 (95% CI: -4.29 to -0.07, p = 0.000, I2 = 94.0%). Adverse events showed a RR of 0.81 (95% CI: 0.50 to 1.30, p = 0.021, I2 = 51.1%), indicating similar safety profiles in both groups.

Conclusion: Our findings indicate that alginate dressings not only significantly reduce healing time but also offer clinically relevant benefits, including reduced pain and fewer dressing changes, making them a valuable option in burn wound management. However, their effect on dressing change frequency and adverse events remains comparable to control treatments. Despite the methodological limitations such as high heterogeneity and potential biases, alginate dressings maintain advantages in clinical settings. Standardization of evaluation criteria and long-term studies are necessary to enhance the understanding and application of alginate dressings in diverse burn wound and donor site wound care settings.

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来源期刊
BMC Surgery
BMC Surgery SURGERY-
CiteScore
2.90
自引率
5.30%
发文量
391
审稿时长
58 days
期刊介绍: BMC Surgery is an open access, peer-reviewed journal that considers articles on surgical research, training, and practice.
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