冠状病毒诱导的神经炎症中年龄依赖性神经胶质细胞与外周免疫细胞的相互作用,特别强调COVID-19

IF 4.1 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Satavisha Ghosh, Jayasri Das Sarma
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引用次数: 0

摘要

神经退行性疾病是一种慢性进行性疾病,会损害记忆、认知和运动功能,导致痴呆、肌肉无力和语言障碍等病症。衰老破坏了促炎性和抗炎性细胞因子之间的严格平衡,增加了神经炎症,从而导致神经退行性疾病。由于免疫反应减弱和受损,以及血脑屏障的完整性受损,衰老的大脑特别容易受到感染,从而使病毒等病原体引发神经退行性变。冠状病毒与急性和长期神经系统并发症有关,包括认知障碍、精神障碍和神经炎症。这种病毒可以引发细胞因子风暴,破坏中枢神经系统,使现有的神经系统状况恶化。尽管其侵袭神经的确切机制尚不清楚,但有证据表明,它会破坏血脑屏障,引发免疫失调,导致老年人持续的神经系统后遗症。本文旨在了解老年人外周免疫系统与中枢神经系统胶质细胞之间的相互作用,这对于解决冠状病毒诱导的神经炎症和伴随的神经退行性变是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19.

Neurodegenerative diseases are chronic progressive disorders that impair memory, cognition, and motor functions, leading to conditions such as dementia, muscle weakness, and speech difficulties. Aging disrupts the stringent balance between pro- and anti-inflammatory cytokines, increasing neuroinflammation, which contributes to neurodegenerative diseases. The aging brain is particularly vulnerable to infections due to a weakened and compromised immune response and impaired integrity of the blood-brain barrier, allowing pathogens like viruses to trigger neurodegeneration. Coronaviruses have been linked to both acute and long-term neurological complications, including cognitive impairments, psychiatric disorders, and neuroinflammation. The virus can induce a cytokine storm, damaging the central nervous system (CNS) and worsening existing neurological conditions. Though its exact mechanism of neuroinvasion remains elusive, evidence suggests it disrupts the blood-brain barrier and triggers immune dysregulation, leading to persistent neurological sequelae in elderly individuals. This review aims to understand the interaction between the peripheral immune system and CNS glial cells in aged individuals, which is imperative in addressing coronavirus-induced neuroinflammation and concomitant neurodegeneration.

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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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