人乳头瘤病毒癌蛋白机制的研究进展。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Denise Ijeoma Obanya, Louisa M Wootton, Ethan L Morgan
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引用次数: 0

摘要

高危人类乳头瘤病毒(hpv)是几乎所有宫颈癌病例和越来越多的口咽癌和肛门生殖器癌的原因。原发性HPV癌蛋白E6和E7共同作用,操纵多种细胞途径,最终导致恶性转化。这包括调节细胞增殖、细胞周期进展和细胞存活的几个信号通路的解除管制。虽然HPV E6和E7在驱动肿瘤发生中的多种功能是众所周知的,但最近的研究发现了HPV癌蛋白的新致癌功能,包括操纵癌症发展的新机制,如表观遗传修饰、细胞可塑性和基因组不稳定性。这篇综述探讨了HPV癌蛋白如何与这些细胞过程相互作用的最新进展,强调了HPV相关癌症的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in understanding the mechanisms of the human papillomavirus oncoproteins.

High-risk human papillomaviruses (HPVs) are responsible for almost all cervical cancer cases and a growing number of oropharyngeal and anogenital cancers. The primary HPV oncoproteins, E6 and E7, act together to manipulate multiple cellular pathways that can ultimately result in malignant transformation. This includes the deregulation of several signalling pathways that regulate cell proliferation, cell cycle progression and cell survival. Although multiple functions of HPV E6 and E7 in driving oncogenesis are well known, recent studies have uncovered novel oncogenic functions of the HPV oncoproteins, including the manipulation of emerging mechanisms of cancer development, such as epigenetic modifications, cellular plasticity and genomic instability. This review explores current advances in understanding how the HPV oncoproteins interact with these cellular processes, highlighting potential therapeutic targets in HPV-associated cancers.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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