Carmela Socolovsky, Margee Louisias, Saleh Alsulami, Carter R Petty, Michelle Trivedi, Peggy S Lai, Amparito Cunningham, Jonathan Gaffin, Peter Thorne, Brent Coull, Petros Koutrakis, Andrea Baccarelli, Diane J Gold, Gary Adamkiewicz, Perdita Permaul, Tina Banzon, Marissa Hauptman, Lisa M Bartnikas, Sachin Baxi, William J Sheehan, Wanda Phipatanakul, Mihail Samnaliev
{"title":"学校综合病虫害管理和空气过滤对哮喘学生的成本效益。","authors":"Carmela Socolovsky, Margee Louisias, Saleh Alsulami, Carter R Petty, Michelle Trivedi, Peggy S Lai, Amparito Cunningham, Jonathan Gaffin, Peter Thorne, Brent Coull, Petros Koutrakis, Andrea Baccarelli, Diane J Gold, Gary Adamkiewicz, Perdita Permaul, Tina Banzon, Marissa Hauptman, Lisa M Bartnikas, Sachin Baxi, William J Sheehan, Wanda Phipatanakul, Mihail Samnaliev","doi":"10.2500/aap.2025.46.250018","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> The cost-effectiveness of school environmental remediation in asthma is not known. The School Inner City Asthma Intervention Study (SICAS2) was a randomized controlled trial that assessed school integrated pest management (IPM) and classroom high efficiency particulate air (HEPA) filtration on asthma morbidity in urban schools. <b>Objective:</b> The objective was to evaluate the cost-effectiveness of SICAS2. <b>Methods:</b> We conducted a cost-effectiveness analysis from a societal perspective that compared four interventions: IPM, HEPA, IPM + HEPA, and no intervention. Quality-adjusted life years (QALY) were derived from the EuroQol-5 Dimension-Youth and EuroQol-5 Dimension-3 levels instruments. Total costs (2021 U.S. dollars) included intervention cost, cost of caregiver productivity impacted by child school absenteeism, and health-care utilization costs (e.g., emergency department visits). The evaluation period was based on a mean follow-up time of 166 days. Sensitivity analyses were performed by using cost estimates 50% above and below initial cost benchmarks. <b>Results:</b> A total of 154 SICAS2 participants were included. Intervention costs per student were $12.21 (IPM + HEPA), $7.27 (IPM), and $4.94 (HEPA). Sequential analyses revealed that IPM + HEPA was the most cost-effective option, with an incremental cost-effectiveness ratio of $19,667 per QALY. Sensitivity analyses demonstrated stability, with variability in probability estimates not exceeding 10%. <b>Conclusion:</b> IPM + HEPA demonstrated good value to society, which reflected the low cost and the economic impact of missed school days. This intervention may have a pronounced benefit for historically minoritized and marginalized children in urban schools who are disproportionately exposed to air pollution and indoor allergens. The SICAS2 intervention may offer a cost-effective tool to target proximal causes of disparities even in the most resource-limited schools.</p>","PeriodicalId":7646,"journal":{"name":"Allergy and asthma proceedings","volume":"46 3","pages":"257-266"},"PeriodicalIF":2.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118139/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cost-effectiveness of school integrated pest management and air filtration in students with asthma.\",\"authors\":\"Carmela Socolovsky, Margee Louisias, Saleh Alsulami, Carter R Petty, Michelle Trivedi, Peggy S Lai, Amparito Cunningham, Jonathan Gaffin, Peter Thorne, Brent Coull, Petros Koutrakis, Andrea Baccarelli, Diane J Gold, Gary Adamkiewicz, Perdita Permaul, Tina Banzon, Marissa Hauptman, Lisa M Bartnikas, Sachin Baxi, William J Sheehan, Wanda Phipatanakul, Mihail Samnaliev\",\"doi\":\"10.2500/aap.2025.46.250018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> The cost-effectiveness of school environmental remediation in asthma is not known. The School Inner City Asthma Intervention Study (SICAS2) was a randomized controlled trial that assessed school integrated pest management (IPM) and classroom high efficiency particulate air (HEPA) filtration on asthma morbidity in urban schools. <b>Objective:</b> The objective was to evaluate the cost-effectiveness of SICAS2. <b>Methods:</b> We conducted a cost-effectiveness analysis from a societal perspective that compared four interventions: IPM, HEPA, IPM + HEPA, and no intervention. Quality-adjusted life years (QALY) were derived from the EuroQol-5 Dimension-Youth and EuroQol-5 Dimension-3 levels instruments. Total costs (2021 U.S. dollars) included intervention cost, cost of caregiver productivity impacted by child school absenteeism, and health-care utilization costs (e.g., emergency department visits). The evaluation period was based on a mean follow-up time of 166 days. Sensitivity analyses were performed by using cost estimates 50% above and below initial cost benchmarks. <b>Results:</b> A total of 154 SICAS2 participants were included. Intervention costs per student were $12.21 (IPM + HEPA), $7.27 (IPM), and $4.94 (HEPA). Sequential analyses revealed that IPM + HEPA was the most cost-effective option, with an incremental cost-effectiveness ratio of $19,667 per QALY. Sensitivity analyses demonstrated stability, with variability in probability estimates not exceeding 10%. <b>Conclusion:</b> IPM + HEPA demonstrated good value to society, which reflected the low cost and the economic impact of missed school days. This intervention may have a pronounced benefit for historically minoritized and marginalized children in urban schools who are disproportionately exposed to air pollution and indoor allergens. 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Cost-effectiveness of school integrated pest management and air filtration in students with asthma.
Background: The cost-effectiveness of school environmental remediation in asthma is not known. The School Inner City Asthma Intervention Study (SICAS2) was a randomized controlled trial that assessed school integrated pest management (IPM) and classroom high efficiency particulate air (HEPA) filtration on asthma morbidity in urban schools. Objective: The objective was to evaluate the cost-effectiveness of SICAS2. Methods: We conducted a cost-effectiveness analysis from a societal perspective that compared four interventions: IPM, HEPA, IPM + HEPA, and no intervention. Quality-adjusted life years (QALY) were derived from the EuroQol-5 Dimension-Youth and EuroQol-5 Dimension-3 levels instruments. Total costs (2021 U.S. dollars) included intervention cost, cost of caregiver productivity impacted by child school absenteeism, and health-care utilization costs (e.g., emergency department visits). The evaluation period was based on a mean follow-up time of 166 days. Sensitivity analyses were performed by using cost estimates 50% above and below initial cost benchmarks. Results: A total of 154 SICAS2 participants were included. Intervention costs per student were $12.21 (IPM + HEPA), $7.27 (IPM), and $4.94 (HEPA). Sequential analyses revealed that IPM + HEPA was the most cost-effective option, with an incremental cost-effectiveness ratio of $19,667 per QALY. Sensitivity analyses demonstrated stability, with variability in probability estimates not exceeding 10%. Conclusion: IPM + HEPA demonstrated good value to society, which reflected the low cost and the economic impact of missed school days. This intervention may have a pronounced benefit for historically minoritized and marginalized children in urban schools who are disproportionately exposed to air pollution and indoor allergens. The SICAS2 intervention may offer a cost-effective tool to target proximal causes of disparities even in the most resource-limited schools.
期刊介绍:
Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.