上了年纪的女性有锻炼的黄金时间吗？雌二醇在调节血管内皮功能中的女性特异性作用研究进展。

IF 2.3 3区医学 Q3 PHYSIOLOGY

American journal of physiology. Regulatory, integrative and comparative physiology Pub Date : 2025-07-01 Epub Date: 2025-05-17 DOI:10.1152/ajpregu.00163.2024

Hollie Speer, Joseph M Northey

引用次数: 0

摘要

性激素在生殖健康中的作用是众所周知的；然而，它们对非生殖组织（如脉管系统）产生辅助作用，特别是涉及内皮血管舒张和血管收缩的调解。绝经过渡期雌激素的突然下降与内皮功能障碍和随后心血管事件的增加有关。毫不奇怪，参与体育活动和锻炼被推荐为增强内皮功能的常见策略，不同运动方式对血管健康结果和风险调节的有效性已被广泛研究。然而，尽管人们意识到绝经期间和绝经后心血管疾病（CVD）风险增加，但在这一关键时期，围绕运动作为增强女性内皮功能的手段的有效性，存在相互矛盾的证据。这篇前瞻性文章旨在讨论雌二醇对女性内皮功能影响的现有证据，以及是否有可能通过在围绝经期进行干预，在育龄后期进行运动，从而获得更大的血管益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of physiology. Regulatory, integrative and comparative physiology 医学-生理学

CiteScore

5.30

自引率

3.60%

发文量

145

审稿时长

2 months

期刊介绍： The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.