Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han
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Studies have shown that CENP-F is closely involved in the pathogenesis of various diseases, particularly in the development and progression of malignant tumors, where it exhibits significant oncogenic activity.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>This review aims to systematically summarize the molecular structure, subcellular localization, expression regulation, intracellular transport mechanisms, biological functions, and carcinogenic mechanisms of CENP-F, as well as explore its potential value in cancer diagnosis and therapy.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A comprehensive review and analysis of domestic and international research literature related to CENP-F were conducted, focusing on its role in tumorigenesis, development, and as a therapeutic target.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>CENP-F acts as an oncogene and can maintain or promote the malignant phenotype of tumor cells through multiple mechanisms, including regulating signaling pathways related to cell proliferation and apoptosis, promoting metabolic reprogramming, angiogenesis, and tumor cell invasion and metastasis. Additionally, it plays an important role in the immune microenvironment and drug resistance regulation.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>CENP-F plays a key, multidimensional role in tumor biology and is a promising therapeutic target for cancer treatment. Further exploration of the core pathways through which CENP-F regulates tumorigenesis and its potential for clinical translation is needed.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 10","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70949","citationCount":"0","resultStr":"{\"title\":\"Centromere Protein F in Tumor Biology: Cancer's Achilles Heel\",\"authors\":\"Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han\",\"doi\":\"10.1002/cam4.70949\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Centromere protein F (CENP-F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation. 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引用次数: 0
摘要
着丝粒蛋白F （cenromere protein F, CENP-F）是一种重要的调节有丝分裂和细胞周期的核基质蛋白，在募集纺锤体检查点蛋白以维持染色体分离的准确性方面起着至关重要的作用。研究表明，CENP-F密切参与多种疾病的发病机制，特别是在恶性肿瘤的发生发展中，表现出显著的致癌活性。目的系统综述CENP-F的分子结构、亚细胞定位、表达调控、细胞内转运机制、生物学功能、致癌机制等方面的研究进展，探讨其在肿瘤诊断和治疗中的潜在价值。方法对国内外有关CENP-F的研究文献进行综述和分析，重点分析其在肿瘤发生、发展和作为治疗靶点中的作用。结果CENP-F作为癌基因，通过调控细胞增殖和凋亡相关信号通路、促进代谢重编程、血管生成、肿瘤细胞侵袭转移等多种机制维持或促进肿瘤细胞的恶性表型。此外，它还在免疫微环境和耐药调控中发挥重要作用。结论CENP-F在肿瘤生物学中起着关键的、多方面的作用，是一个有前景的肿瘤治疗靶点。需要进一步探索CENP-F调节肿瘤发生的核心途径及其临床转化的潜力。
Centromere Protein F in Tumor Biology: Cancer's Achilles Heel
Background
Centromere protein F (CENP-F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation. Studies have shown that CENP-F is closely involved in the pathogenesis of various diseases, particularly in the development and progression of malignant tumors, where it exhibits significant oncogenic activity.
Objective
This review aims to systematically summarize the molecular structure, subcellular localization, expression regulation, intracellular transport mechanisms, biological functions, and carcinogenic mechanisms of CENP-F, as well as explore its potential value in cancer diagnosis and therapy.
Methods
A comprehensive review and analysis of domestic and international research literature related to CENP-F were conducted, focusing on its role in tumorigenesis, development, and as a therapeutic target.
Results
CENP-F acts as an oncogene and can maintain or promote the malignant phenotype of tumor cells through multiple mechanisms, including regulating signaling pathways related to cell proliferation and apoptosis, promoting metabolic reprogramming, angiogenesis, and tumor cell invasion and metastasis. Additionally, it plays an important role in the immune microenvironment and drug resistance regulation.
Conclusion
CENP-F plays a key, multidimensional role in tumor biology and is a promising therapeutic target for cancer treatment. Further exploration of the core pathways through which CENP-F regulates tumorigenesis and its potential for clinical translation is needed.
期刊介绍：
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas:
Clinical Cancer Research
Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations
Cancer Biology:
Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery.
Cancer Prevention:
Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach.
Bioinformatics:
Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers.
Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
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