Kayoung Shin, Yeonjae Kim, Sungwoo Kim, Hyun Jung Kim, Sekyoo Jeong, Mi Jang, Jeong Ho Park, Gaewon Nam
{"title":"新合成的具有自噬刺激活性抗氧化剂的抗糖基化和抗衰老作用","authors":"Kayoung Shin, Yeonjae Kim, Sungwoo Kim, Hyun Jung Kim, Sekyoo Jeong, Mi Jang, Jeong Ho Park, Gaewon Nam","doi":"10.1111/jocd.70240","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The accumulation of advanced glycation end products (AGEs) in aged skin and their pro-aging effects suggest the potential application of anti-glycation ingredients as skin anti-aging agents.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>This study evaluated the anti-aging efficacy of a newly developed anti-glycation ingredient with antioxidant and autophagy-stimulating activities through in vitro, ex vivo, and clinical efficacy tests.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>AGEs formation in both the cell-free BSA/glyoxal system and glucose/glyoxal-treated human epidermal keratinocytes was measured, while the degradation of pre-formed BSA/AGEs by keratinocytes was assessed. Anti-glycation and anti-inflammatory effects were further examined using <i>an</i> ex vivo human skin explant model. Clinical anti-aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The tested ingredient inhibited AGE formation and accelerated the degradation of pre-formed AGEs in vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4 weeks of test product application.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>A newly synthesized antioxidant with autophagy-stimulating activity exhibited significant anti-glycation efficacy in both in vitro and clinical studies, suggesting its potential as an effective skin anti-aging ingredient.</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70240","citationCount":"0","resultStr":"{\"title\":\"Anti-Glycation and Anti-Aging Efficacy of Newly Synthesized Antioxidant With Autophagy Stimulating Activity\",\"authors\":\"Kayoung Shin, Yeonjae Kim, Sungwoo Kim, Hyun Jung Kim, Sekyoo Jeong, Mi Jang, Jeong Ho Park, Gaewon Nam\",\"doi\":\"10.1111/jocd.70240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The accumulation of advanced glycation end products (AGEs) in aged skin and their pro-aging effects suggest the potential application of anti-glycation ingredients as skin anti-aging agents.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>This study evaluated the anti-aging efficacy of a newly developed anti-glycation ingredient with antioxidant and autophagy-stimulating activities through in vitro, ex vivo, and clinical efficacy tests.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>AGEs formation in both the cell-free BSA/glyoxal system and glucose/glyoxal-treated human epidermal keratinocytes was measured, while the degradation of pre-formed BSA/AGEs by keratinocytes was assessed. Anti-glycation and anti-inflammatory effects were further examined using <i>an</i> ex vivo human skin explant model. Clinical anti-aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The tested ingredient inhibited AGE formation and accelerated the degradation of pre-formed AGEs in vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4 weeks of test product application.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>A newly synthesized antioxidant with autophagy-stimulating activity exhibited significant anti-glycation efficacy in both in vitro and clinical studies, suggesting its potential as an effective skin anti-aging ingredient.</p>\\n </section>\\n </div>\",\"PeriodicalId\":15546,\"journal\":{\"name\":\"Journal of Cosmetic Dermatology\",\"volume\":\"24 5\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70240\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cosmetic Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70240\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70240","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Anti-Glycation and Anti-Aging Efficacy of Newly Synthesized Antioxidant With Autophagy Stimulating Activity
Background
The accumulation of advanced glycation end products (AGEs) in aged skin and their pro-aging effects suggest the potential application of anti-glycation ingredients as skin anti-aging agents.
Aims
This study evaluated the anti-aging efficacy of a newly developed anti-glycation ingredient with antioxidant and autophagy-stimulating activities through in vitro, ex vivo, and clinical efficacy tests.
Methods
AGEs formation in both the cell-free BSA/glyoxal system and glucose/glyoxal-treated human epidermal keratinocytes was measured, while the degradation of pre-formed BSA/AGEs by keratinocytes was assessed. Anti-glycation and anti-inflammatory effects were further examined using an ex vivo human skin explant model. Clinical anti-aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.
Results
The tested ingredient inhibited AGE formation and accelerated the degradation of pre-formed AGEs in vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4 weeks of test product application.
Conclusion
A newly synthesized antioxidant with autophagy-stimulating activity exhibited significant anti-glycation efficacy in both in vitro and clinical studies, suggesting its potential as an effective skin anti-aging ingredient.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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