热老化对含抗菌甲基丙烯酸季铵聚氨酯基3D打印树脂的影响

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-05-15 DOI:10.1016/j.jmbbm.2025.107063

Gan Jin , Yunqi Liu , Zhihao Zhang , Yeonwoo Yim , Dae Gyun Lee , Min Suk Shim , Reuben Kim , Jong-Eun Kim

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引用次数: 0

摘要

目的研究热老化对含甲基丙烯酸二甲胺十六烷基酯（DMAHDM）丙烯酸氨基酯基（UA） 3D打印树脂的力学性能、生物相容性和抗菌性能的影响。方法合成sdmahdm，分别以0.25 wt%、0.5 wt%、0.75 wt%、1 wt%的浓度掺入UA树脂中。样品进行3D打印、清洗、后固化，并在5°C和55°C下进行833、2500和5000次循环。以无DMAHDM组和无衰老组为对照组。对转化度（DC）、色差、抗菌效果、细胞活力和机械性能进行了评估。进行双向方差分析，显著性截断为α = 0.05。结果DC随DMAHDM浓度的增加而增加，最高DC为1 wt%(53.68±0.35%)（平均值±标准差）。经过2500次和5000次循环后，样品的颜色发生了显著变化。0.75 wt%和1 wt%的DMAHDM可提高抗菌效果。延长热老化周期观察细胞毒性。抗弯强度随着DMAHDM浓度的增加和老化而降低，在5000次循环后，其最低值为1wt %（93.02±17.96 MPa）。然而，随着DMAHDM和时效的增加，维氏硬度显著增加，在5000次循环时达到峰值（24.49±0.96 HV）。结论sdmahdm浓度和热老化对丙烯酸基3D打印树脂的性能有显著影响。在0.75 wt%后，较高的DMAHDM浓度提高了抗菌效果和维氏硬度，但降低了抗弯强度。热老化降低了抗弯强度，但提高了直流和硬度。长时间的衰老也会导致颜色变化和细胞毒性增加。

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Effect of thermal aging on a urethane acrylate-based 3D printing resin incorporated with antibacterial quaternary ammonium methacrylate

Purpose

This study aimed to determine the impacts of thermal aging on the mechanical properties, biocompatibility, and antibacterial effectiveness of a urethane acrylate-based (UA) 3D printing resin containing dimethylaminohexadecyl methacrylate (DMAHDM).

Methods

DMAHDM was synthesized and incorporated into UA resin at 0.25 wt%, 0.5 wt%, 0.75 wt%, and 1 wt%. Specimens were 3D printed, washed, post-cured, and thermal cycled at 5 °C and 55 °C for 833, 2500, and 5000 cycles. The group without DMAHDM or aging was considered as the control group. Degree of conversion (DC), color differences, antibacterial effectiveness, cell viability, and mechanical properties were evaluated. Two-way analysis of variance was performed with a significance cutoff of α = 0.05.

Results

DC increased with the DMAHDM concentration, with the highest DC being observed at 1 wt% (53.68 ± 0.35 %) (mean ± standard deviation). The color of the specimens showed significant changes after 2500 and 5000 cycles. Antibacterial effectiveness was improved with 0.75 wt% and 1 wt% DMAHDM. Cytotoxicity was observed with prolonged thermal aging cycles. Flexural strength decreased with increasing DMAHDM concentrations and aging, with the lowest values at 1 wt% (93.02 ± 17.96 MPa) after 5000 cycles. However, Vickers hardness significantly increased with both DMAHDM and aging, reaching a peak at 5000 cycles (24.49 ± 0.96 HV).

Conclusions

DMAHDM concentration and thermal aging significantly influenced UA-based 3D printing resins properties. Higher DMAHDM concentration enhanced antibacterial effectiveness and Vickers hardness yet reduced flexural strength after 0.75 wt%. Thermal aging decreased flexural strength while improving DC and hardness. Prolonged aging also led to color changes and increased cytotoxicity.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.