成熟微血管和失活微血管在股髋臼撞击和髋关节骨关节炎患者的乳晕滑膜中表现突出

Ronan J. Anderson , Brent A. Lanting , C. Thomas Appleton , Ryan M. Degen
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引用次数: 0

摘要

目的探讨髋关节骨关节炎(OA)发病机制的早期变化。对股髋臼撞击(FAI)、FAI合并早期髋关节骨关节炎和晚期髋关节骨关节炎患者的滑膜组织病理学进行了研究。方法对10例FAI患者、14例伴有早期骨关节炎的FAI患者和12例晚期骨关节炎患者行滑膜活检。组织病理学分级允许评估骨关节炎相关特征。通过免疫荧光标记CD31和α-平滑肌肌动蛋白检测微血管密度和成熟度。应用免疫组织化学染色计算CD105+微血管密度,深入了解微血管活性。结果各组血管化明显,平均[95%可信区间]为1.64[1.40,1.89]。在所有三组中,成熟微血管密度均大于未成熟微血管密度(82.32[62.92,101.71]对14.84[9.86,19.83]微血管/mm2)。各组CD105+微血管密度均较低(3.14[0.92,5.37]微血管/mm2),表明微血管不活跃。晚期OA患者的炎症综合评分(1.08[0.84,1.32])明显高于FAI组(0.47[0.26,0.68]),晚期OA患者的炎症综合评分明显高于FAI合并早期OA组(0.69 [0.49,0.89])(p <;0.017)。结论FAI患者(伴或不伴髋关节骨关节炎)的滑膜表现为滑膜炎和其他oa相关改变。成熟的、失活的微血管在所有三组中都很突出。FAI和髋关节OA滑膜的组织病理学相似性表明FAI患者出现滑膜紊乱。这些发现强调了滑膜改变在从FAI到髋关节OA进展中的潜在作用,强调了早期干预和进一步研究早期疾病机制的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients

Objective

To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoarthritis, and advanced hip osteoarthritis.

Methods

Synovium biopsies were collected from ten FAI, fourteen FAI with early osteoarthritis, and twelve advanced osteoarthritis patients. Histopathological grading allowed assessment of osteoarthritis-associated features. Microvessel density and maturity were determined through immunofluorescent labelling of CD31 and α-smooth muscle actin. Immunohistochemical staining was applied to calculate CD105+ microvessel density, providing insight into microvessel activity.

Results

In all groups, vascularization was prominent, with a mean [95 ​% confidence interval] of 1.64 [1.40, 1.89]. In all three groups, mature microvessel density was greater than immature microvessel density (82.32 [62.92, 101.71] versus 14.84 [9.86, 19.83] microvessels/mm2). Low CD105+ microvessel density across all groups (3.14 [0.92, 5.37] microvessels/mm2) suggests microvessel inactivity. Inflammatory composite scores were significantly greater in the advanced OA (1.08 [0.84, 1.32]) versus the FAI group (0.47 [0.26, 0.68]), and in the advanced OA versus the FAI with early OA group (0.69 [0.49, 0.89]) (p ​< ​0.017).

Conclusion

Synovium from patients with FAI (with and without hip osteoarthritis) demonstrated synovitis and other OA-associated changes. Mature, inactive microvasculature was prominent in all three groups investigated. Histopathological similarities between FAI and hip OA synovium indicate that disordered synovium appears in FAI patients. These findings highlight a potential role of synovial changes in the progression from FAI to hip OA, underscoring the need for early intervention and further investigation into early disease mechanisms.
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来源期刊
Osteoarthritis and cartilage open
Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation
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