碱促进原位形成的偶氮-邻醌方法的加氢磷酸化制备2-氨基苯基氧化磷

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-15 DOI:10.1016/j.tetlet.2025.155658

Mengjie Gong , Fuxing Yang , Nan Huang, Jun Jiang

引用次数: 0

摘要

本文报道了以N-（邻氯甲基）芳基酰胺为原料，碱基促进原位合成偶氮-邻醌（aza-o-QMs）的1,4-氢化反应。二芳基膦氧化物和亚磷酸盐在这些反应中是有效的亲核试剂。该方法具有底物范围广、操作简单、条件温和、产率高等优点，为合成各种2-氨基苯基磷氧化物提供了一种替代策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Base-promoted hydrophosphination of in situ formed aza-ortho-quinone methides for the preparation of 2-aminobenzyl phosphorus oxides

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Base-promoted hydrophosphination of in situ formed aza-ortho-quinone methides for the preparation of 2-aminobenzyl phosphorus oxides

A base-promoted 1,4-hydrophosphination of in situ generated aza-ortho-quinone methides (aza-o-QMs) from N-(ortho-chloromethyl)aryl amides was reported in this work. Diarylphosphine oxides and phosphites serve as efficient P-nucleophiles in these reactions. The advantages of this method include a broad substrate scope, operational simplicity, mild conditions, and high yields, providing an alternative strategy for synthesizing various 2-aminobenzyl phosphorus oxides.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.