非编码RNA为学习和记忆的分子和细胞底物提供代理

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-05-19 DOI:10.1016/j.conb.2025.103044

Alexander D. Walsh , Timothy W. Bredy

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引用次数: 0

摘要

在过去的十年中，对大脑中非编码RNA （ncRNA）的认识和研究出现了爆炸式的增长。快速出现的证据表明，许多种类的ncRNA通过精确的亚细胞定位和与DNA、mRNA和RNA结合蛋白的相互作用来协调与学习和记忆相关的过程。在这里，我们使用最近发现和研究充分的ncRNAs的例子来讨论这些机制，包括长链非编码rna (lncRNAs)，环状rna （circRNAs）和微rna (miRNAs)，它们直接参与调节经验依赖的神经可塑性。

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Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory

In the past decade, there has been a virtual explosion in the appreciation and study of noncoding RNA (ncRNA) in the brain. Rapidly emerging evidence suggests that many classes of ncRNA coordinate processes related to learning and memory, achieved via their precise subcellular localisation and interactions with DNA, mRNA and RNA binding proteins. Here we discuss these mechanisms using examples of recently discovered and well-studied ncRNAs, including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs), which are directly involved in regulating experience-dependent neural plasticity.

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience