细胞外囊泡及其模拟物：医学美学的临床应用前景

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-05-14 DOI:10.1093/burnst/tkaf033

Zixuan Sun, Jiali Li, Zhijing Wu, Jiaxin Zhang, Tangrong Wang, Yuzhou Zheng, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan

{"title":"细胞外囊泡及其模拟物：医学美学的临床应用前景","authors":"Zixuan Sun, Jiali Li, Zhijing Wu, Jiaxin Zhang, Tangrong Wang, Yuzhou Zheng, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan","doi":"10.1093/burnst/tkaf033","DOIUrl":null,"url":null,"abstract":"The persistent desire for beauty has fueled the rapid development of medical aesthetics. Multiple approaches, including cosmetics, drugs, and cell therapies, have been developed to improve skin conditions. However, none of these methods achieves the intended outcomes and may produce adverse repercussions. Consequently, it is crucial to develop effective and safe therapies to promote skin repair and regeneration. Extracellular vesicles (EVs) are cell-derived, lipid bilayer-encapsulated nanoparticles containing multiple active components. There is now strong evidence that EV therapies can improve skin barrier function, reduce scarring, inhibit aging and pigmentation, and suppress hair loss, highlighting the potential for cosmeceutical development based on EVs. This review summarizes the latest applications of natural EVs, preconditioned and engineered EVs, and EV mimetics in medical aesthetics. Additionally, the article discusses advanced delivery strategies for EVs and the commercial prospects of EVs and provides insights into present security concerns, regulations, and the field’s future directions.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"16 1","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extracellular vesicles and their mimetics: clinical application prospects in medical aesthetics\",\"authors\":\"Zixuan Sun, Jiali Li, Zhijing Wu, Jiaxin Zhang, Tangrong Wang, Yuzhou Zheng, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan\",\"doi\":\"10.1093/burnst/tkaf033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The persistent desire for beauty has fueled the rapid development of medical aesthetics. Multiple approaches, including cosmetics, drugs, and cell therapies, have been developed to improve skin conditions. However, none of these methods achieves the intended outcomes and may produce adverse repercussions. Consequently, it is crucial to develop effective and safe therapies to promote skin repair and regeneration. Extracellular vesicles (EVs) are cell-derived, lipid bilayer-encapsulated nanoparticles containing multiple active components. There is now strong evidence that EV therapies can improve skin barrier function, reduce scarring, inhibit aging and pigmentation, and suppress hair loss, highlighting the potential for cosmeceutical development based on EVs. This review summarizes the latest applications of natural EVs, preconditioned and engineered EVs, and EV mimetics in medical aesthetics. Additionally, the article discusses advanced delivery strategies for EVs and the commercial prospects of EVs and provides insights into present security concerns, regulations, and the field’s future directions.\",\"PeriodicalId\":9553,\"journal\":{\"name\":\"Burns & Trauma\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Burns & Trauma\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/burnst/tkaf033\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Burns & Trauma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/burnst/tkaf033","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

对美的执着追求推动了医学美学的快速发展。包括化妆品、药物和细胞疗法在内的多种方法已经被开发出来，以改善皮肤状况。然而，这些方法都没有达到预期的结果，并可能产生不利的影响。因此，开发有效和安全的治疗方法来促进皮肤修复和再生是至关重要的。细胞外囊泡（EVs）是细胞衍生的，脂质双层包裹的纳米颗粒，含有多种活性成分。现在有强有力的证据表明，电动汽车疗法可以改善皮肤屏障功能，减少疤痕，抑制衰老和色素沉着，抑制脱发，突出了基于电动汽车的药妆开发的潜力。本文综述了天然电动汽车、预处理电动汽车、工程电动汽车以及仿生电动汽车在医学美学中的最新应用。此外，本文还讨论了电动汽车的先进交付策略和电动汽车的商业前景，并提供了对当前安全问题、法规和该领域未来方向的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Extracellular vesicles and their mimetics: clinical application prospects in medical aesthetics

The persistent desire for beauty has fueled the rapid development of medical aesthetics. Multiple approaches, including cosmetics, drugs, and cell therapies, have been developed to improve skin conditions. However, none of these methods achieves the intended outcomes and may produce adverse repercussions. Consequently, it is crucial to develop effective and safe therapies to promote skin repair and regeneration. Extracellular vesicles (EVs) are cell-derived, lipid bilayer-encapsulated nanoparticles containing multiple active components. There is now strong evidence that EV therapies can improve skin barrier function, reduce scarring, inhibit aging and pigmentation, and suppress hair loss, highlighting the potential for cosmeceutical development based on EVs. This review summarizes the latest applications of natural EVs, preconditioned and engineered EVs, and EV mimetics in medical aesthetics. Additionally, the article discusses advanced delivery strategies for EVs and the commercial prospects of EVs and provides insights into present security concerns, regulations, and the field’s future directions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.