白质间质液增加与脑小血管疾病负担相关的髓深静脉可见性降低

Zhihua Xu, Haiyuan Lan, Xinjun Lei, Hongxia Zhang, Fanfan Xiong, Lebing Wang
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引用次数: 0

摘要

背景和目的:在脑小血管疾病(CSVD)患者中,有报道称在敏感性加权成像(SWI)上深髓静脉(DMVs)的可见性降低。本研究旨在探讨DMV、间质液(ISF)可见度降低与CSVD负担之间的关系。材料和方法:对128例CSVD患者进行多模MRI检查。DMV评分用于对DMV在SWI上的可见性进行评分。用白质扩散张量成像的平均自由水(FW)评价ISF。评估CSVD负担,包括MRI上各CSVD标志物的严重程度和CSVD MR总评分。结果:DMV评分与各CSVD影像学指标的严重程度及总CSVD MR评分相关(P < 0.05)。此外,DMV评分对CSVD显像标志物[白质高强度(WMH)、脑微出血(CMB)和腔隙性梗死(LI)]的严重程度和FW介导的CSVD MR总评分的间接影响也很显著[WMH: β, 95% CI: 0.13 (0.05, 0.24);Li: β, 95% ci: 0.19 (0.06, 0.32);Cmb: β, 95% ci: 0.13 (0.01, 0.30);总CSVD MR评分:β, 95% CI: 0.16(0.05, 0.29)]与年龄和血管危险因素控制。结论:DMV评分与CSVD患者白质中FW与CSVD负担相关,并可能描述CSVD负担发病机制的静脉方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter.

Background and purpose: Decreased visibility of deep medullary veins (DMVs) on susceptibility-weighted imaging (SWI) has been reported in individuals with cerebral small vessel disease (CSVD). This study aims to explore the relationship between the decreased visibility of the DMV, interstitial fluid (ISF), and the CSVD burden.

Materials and methods: Patients with CSVD (n = 128) were enrolled with multimode MRI. The DMV score was used to score visibility of DMVs on SWI. ISF was evaluated by mean free water (FW) on diffusion tensor imaging in white matter. CSVD burden was evaluated, including the severity of each CSVD marker at MRI and total CSVD MR score.

Results: The DMV score was associated with the severity of each CSVD imaging marker and total CSVD MR score (P < .05). Further, the indirect effect of the DMV score on the severity of CSVD imaging makers [white matter hyperintensity (WMH), cerebral microbleed (CMB) and lacunar infarct (LI)] and total CSVD MR score mediated by FW was significant [WMH: β, 95% CI: 0.13 (0.05, 0.24); LI: β, 95% CI: 0.19 (0.06, 0.32); CMB: β, 95% CI: 0.13 (0.01, 0.30); total CSVD MR score: β, 95% CI: 0.16 (0.05, 0.29)] controlling with age and vascular risk factors.

Conclusions: The DMV score was associated with the CSVD burden through FW in white matter in individuals with CSVD and may describe a venous aspect of the pathogenesis of the CSVD burden.

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