[囊性纤维化和哮喘患者的转变]。

IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-14 DOI:10.1007/s00108-025-01912-6
Margarete Olivier, Florian Stehling, Christian Taube, Matthias Welsner
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引用次数: 0

摘要

对于患有囊性纤维化(CF)和哮喘等慢性疾病的个体来说,青春期是一个重要的转变时期。由于高效囊性纤维化跨膜传导调节剂(CFTR)调制剂治疗的实质性进展,几乎所有CF患者现在都已成年,需要持续的跨学科医疗护理。相反,大约70%的哮喘患儿在成年后症状得到缓解。导致哮喘持续到成年的因素包括严重哮喘的存在、儿童时期肺功能减弱和过敏性合并症。特别是对于患有严重哮喘的年轻成人,必须提供持续的肺炎护理,包括不间断地获得生物制剂。在过渡过程中,关于职业选择的考虑是相关的两组患者。此外,与计划生育和产前诊断相关的问题对患有CF的年轻人尤为重要,应该在过渡过程中加以解决。在这两组患者中,早期和有组织地开始过渡过程是必不可少的。使用检查清单和过渡计划可以促进关键信息的传递,并确保无缝过渡。儿科和内科联合会诊促进信任,确保医疗质量。最终,一个成功的转变应该使CF患者和哮喘患者能够对自己的病情和治疗承担责任,认识到临床恶化,并及时寻求帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Transition in patients with cystic fibrosis and asthma].

Adolescence represents a period of significant transformation for individuals with chronic conditions such as cystic fibrosis (CF) and asthma. Due to substantial progress in highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy, nearly everyone with CF now reaches adulthood, necessitating ongoing interdisciplinary medical care. Conversely, approximately 70% of children with asthma experience a resolution of symptoms as they reach adulthood. Factors contributing to the persistence of asthma into adulthood include the presence of severe asthma, diminished lung function in childhood and allergic comorbidities. Especially for young adults with severe asthma, continuous pneumological care including uninterrupted access to biologics, must be provided. During the transition process, considerations regarding career choices are pertinent for both patient groups. Additionally, issues related to family planning and prenatal diagnostics become particularly relevant for young adults with CF and should be addressed during the transition process. In both patient groups, an early and structured initiation of the transition process is essential. The use of checklists and transition plans can facilitate the transfer of critical information and ensure a seamless transition. Joint pediatric and internal medicine consultations foster trust and ensure medical quality. Ultimately, a successful transition should enable individuals with CF as well as those with asthma to assume responsibility for their condition and treatment, recognize clinical deterioration, and seek timely assistance.

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