Ankaferd止血剂、富血小板血浆和苦瓜对肥胖大鼠坐骨神经损伤的再生作用。

Mehmet Emin Önger, Stefano Geuna, Abubaker El Elhaj, Stefania Raimondo, Suleyman Kaplan
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摘要

目的:肥胖在工业化国家是一种普遍的、潜在的致命疾病,通常是由于卡路里摄入和能量消耗之间的不平衡。采用体视学和电镜技术观察Ankaferd Blood Stopper (ABS)、富血小板血浆(PRP)和苦参(Momordica charantia, MC)对肥胖坐骨神经损伤大鼠的影响。方法:8 ~ 10周龄雌性Sprague Dawley大鼠24只,分为肥胖间隙ABS组、肥胖间隙PRP组和肥胖间隙MC组。从神经分支上方约10毫米处切除5毫米神经阻滞。然后用管状的胶原膜包围和闭合间隙区域。分别在各组试管中注射ABS、PRP、MC等材料。术后12周行肌电图和组织学检查,观察其对神经再生的结构修复和功能促进作用。结果:OGMC中髓鞘轴突数量明显增加。此外,OGMC组的潜伏期值比OGABS和OGPRP组更为关键,表明髓鞘形成更好。PRP和ABS积极影响神经间隙修复,有利于无髓鞘轴突的再生。结论:含有ABS、PRP和MC的胶原管有助于肥胖大鼠周围神经间隙的修复和闭合,有利于周围神经切除和脱髓鞘的闭合。本研究结果表明,胶原蛋白管对肥胖模型周围神经再生具有治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regeneration responses of Ankaferd Blood Stopper, platelet-rich-plasma, andMomordica charantiaon sciatic nerve injury in the obese rats.

Obesity is a prevalent and potentially fatal disorder in industrialized nations, often due to an imbalance between calorie intake and energy expenditure. The study investigates the effects of Ankaferd Blood Stopper (ABS), platelet-rich plasma (PRP), andMomordica charantia(MC) on obese rats with sciatic nerve injuries using stereological and electron microscopic techniques. Twenty-four female Sprague Dawley rats, aged 8-10 weeks, were divided into three groups: the obese gap ABS group (OGABS), the obese gap PRP group (OGPRP), and the obese gap MC group (OGMC). A five-mm nerve block was resected approximately 10 mm above the nerve branch. The gap region was then surrounded and closed by a collagen membrane in tube form. Materials such as ABS, PRP, and MC were injected into the tubes of each group. Electromyography and histological procedures were performed after 12 weeks of surgery to investigate their structural repair and functional promotion of nerve regeneration. A significant increase in the number of myelinated axons in OGMC was found. In addition, the latency values in OGMC were more critical than in the OGABS and OGPRP groups, indicating better myelination. PRP and ABS positively affected nerve gap repair, favoring regenerating unmyelinated axons. Due to increased amplitude values, PRP and ABS have also improved axonal area regeneration. Collagen tubes containing ABS, PRP, and MC may help repair and close peripheral nerve gaps in obese rats, which could be beneficial in closing peripheral nerve resection and demyelination. The study's findings indicate that these collagen tubes can have a therapeutic effect on peripheral nerve regeneration in obese models.

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