一种定量粒子识别(QPID)光谱放射自成像系统。

Stephen S Adler, Noriko Sato, Kwamena E Baidoo, Frank I Lin, Woonghee Lee, Colleen P Olkowski, Freddy E Escorcia, Peter L Choyke
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引用次数: 0

摘要

放射自显影术被用于研究放射性同位素标记的配体在组织中的微尺度分布和结合。该技术自成立以来一直在发展,当时它使用模拟胶片曝光技术,引入了对电离辐射敏感的数字成像系统。我们报道了基于Timepix3传感器和伽玛探测闪烁晶体的定量粒子识别光谱自显影系统(QPID)的开发。该放射自成像系统利用Timepix3的电离辐射检测功能,测量放射性同位素带电粒子的能量沉积,时间分辨率为7.7 ns,全宽半高(FWHM),生成光谱或活动自成像图像。QPID包括一个闪烁晶体,用于记录与Timepix3电离事件一致的伽马辐射,时间分辨率为24.2 ns FWHM。QPID可以分离α和β粒子之间的轨迹,选择特定的沉积能量范围,或者在生成图像时选择在选定的能量范围内是否存在重合的伽马辐射。QPID具有10%的线性响应,对223Ra和18f放射性同位素高达700 Bq和2.5 kBq。使用α和ß+粒子识别滤波器,从同时注入两种放射配体的骨样品中生成223RaCl2和Na18F活性分布的单独图像。这种独特的能力可以通过测量其相对药代动力学特性,为使用治疗性α和β +显像剂的靶向放射治疗研究打开大门。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Quantitative Particle Identification (QPID) spectral autoradiography system.

Autoradiography is used to study the distribution and binding of radioisotope tagged ligands in tissue at microscale among other applications. The technology has evolved since its inception when it used analogue film exposure techniques with the introduction of digital imaging systems sensitive to ionizing radiation. We report on the development of our Quantitative Particle Identification spectral autoradiography system (QPID), which is based on the Timepix3 sensor and a gamma detecting scintillation crystal. This autoradiography system leverages the ionizing radiation detection features of the Timepix3 to measure the energy deposition from charged particles from radioisotopes with a time resolution of 7.7 ns full width at half max (FWHM), generating spectral or activity autoradiography images. The QPID includes a scintillation crystal used to record gamma emissions coincident with the Timepix3 ionization events with a time resolution of 24.2 ns FWHM. The QPID can separate tracks between α and ß particles, select specific ranges of deposited energies or select on the presence of coincident gamma emissions within a selected energy range when generating images. The QPID has a 10% linearity response up to 700 Bq for 223Ra and 2.5 kBq for 18 F radioisotopes. Using α and ß+ particle identification filters, separate images of 223RaCl2 and Na18F activity distributions were generated from a bone sample infused with the two radioligands together. This unique capability can open the door to the study of targeted radiotherapies which use theranostic α and ß+ imaging agents by measuring their relative pharmacokinetic properties.

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