硬纤维瘤治疗观念的演变。

IF 2.5 3区医学 Q2 HEMATOLOGY

Hematology-Oncology Clinics of North America Pub Date : 2025-05-13 DOI:10.1016/j.hoc.2025.04.009

Sylvie Bonvalot, Aisha Miah, Bernd Kasper

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引用次数: 0

摘要

DT是一种罕见的单克隆纤维母细胞肿瘤，具有不可预测的生物学行为。在过去的15年中，世界范围内治疗硬纤维瘤（DT）的方法已经发生了巨大的转变，从可行的手术到大多数情况下的一线主动监测，以选择真正需要治疗的患者。大约50%的病例表现为惰性疾病，而其余患者可能需要积极治疗。手术和放疗的适应症仍然有限，但最近的3项随机试验为医学治疗提供了新的见解。这次审查将突出全球概念和战略的演变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evolving Concepts in the Management of Desmoid Tumors.

DT is a rare monoclonal fibroblastic neoplasm with an unpredictable biologic behavior. Over the past 15 y, the worldwide approach to desmoid tumor (DT) has shifted dramatically from surgery, when feasible, to frontline active surveillance in the majority of cases, to select patients who truly require treatment. Approximately 50% of cases demonstrate indolent disease, while the remaining patients may require active treatment. Surgery and radiotherapy still have limited indications, but 3 recent randomized trials have provided new insights into medical treatments. This review will highlight the evolution of global concepts and strategies.

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来源期刊

Hematology-Oncology Clinics of North America 医学-血液学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.