Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang
{"title":"疫苗接种后血清学检测预防乙型肝炎病毒垂直传播的多区域流行病学评价——中国5省10县2019-2024年","authors":"Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang","doi":"10.46234/ccdcw2025.108","DOIUrl":null,"url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.</p><p><strong>What is added by this report?: </strong>PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.</p><p><strong>What are the implications for public health practice?: </strong>MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"658-664"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075494/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.\",\"authors\":\"Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang\",\"doi\":\"10.46234/ccdcw2025.108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>What is already known about this topic?: </strong>Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.</p><p><strong>What is added by this report?: </strong>PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.</p><p><strong>What are the implications for public health practice?: </strong>MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.</p>\",\"PeriodicalId\":69039,\"journal\":{\"name\":\"中国疾病预防控制中心周报\",\"volume\":\"7 19\",\"pages\":\"658-664\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075494/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国疾病预防控制中心周报\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.46234/ccdcw2025.108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国疾病预防控制中心周报","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.46234/ccdcw2025.108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.
What is already known about this topic?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.
What is added by this report?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.
What are the implications for public health practice?: MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.
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