{"title":"尽管听力图正常,噪声暴露是否与延伸高频听力受损有关?系统回顾和荟萃分析。","authors":"Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta Mishra","doi":"10.1177/23312165251343757","DOIUrl":null,"url":null,"abstract":"<p><p>Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 to 20 kHz region in adults with clinically normal audiograms were included by searching five electronic databases (e.g., PubMed). Cohorts from 30 studies, comprising approximately 2,500 participants, were systematically reviewed. Meta-analysis was conducted on 23 studies using a random-effects model for occupational and recreational noise exposure. Analysis showed a significant positive association between occupational noise and hearing thresholds, with medium effect sizes at 9 and 11.2 kHz and large effect sizes at 10, 12, 14, and 16 kHz. However, the association with recreational noise was less consistent, with significant effects only at 12, 12.5, and 16 kHz. Egger's test indicated some publication bias, specifically at 10 kHz. Findings suggest thresholds above 8 kHz may indicate early noise exposure effects, even when lower-frequency (≤8 kHz) thresholds remain normal. Longitudinal studies incorporating noise dosimetry are crucial to establish causality and further support the clinical utility of extended high-frequency testing.</p>","PeriodicalId":48678,"journal":{"name":"Trends in Hearing","volume":"29 ","pages":"23312165251343757"},"PeriodicalIF":3.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084714/pdf/","citationCount":"0","resultStr":"{\"title\":\"Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite a Normal Audiogram? A Systematic Review and Meta-Analysis.\",\"authors\":\"Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta Mishra\",\"doi\":\"10.1177/23312165251343757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 to 20 kHz region in adults with clinically normal audiograms were included by searching five electronic databases (e.g., PubMed). Cohorts from 30 studies, comprising approximately 2,500 participants, were systematically reviewed. Meta-analysis was conducted on 23 studies using a random-effects model for occupational and recreational noise exposure. Analysis showed a significant positive association between occupational noise and hearing thresholds, with medium effect sizes at 9 and 11.2 kHz and large effect sizes at 10, 12, 14, and 16 kHz. However, the association with recreational noise was less consistent, with significant effects only at 12, 12.5, and 16 kHz. Egger's test indicated some publication bias, specifically at 10 kHz. Findings suggest thresholds above 8 kHz may indicate early noise exposure effects, even when lower-frequency (≤8 kHz) thresholds remain normal. Longitudinal studies incorporating noise dosimetry are crucial to establish causality and further support the clinical utility of extended high-frequency testing.</p>\",\"PeriodicalId\":48678,\"journal\":{\"name\":\"Trends in Hearing\",\"volume\":\"29 \",\"pages\":\"23312165251343757\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084714/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Hearing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/23312165251343757\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Hearing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/23312165251343757","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY","Score":null,"Total":0}
Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite a Normal Audiogram? A Systematic Review and Meta-Analysis.
Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 to 20 kHz region in adults with clinically normal audiograms were included by searching five electronic databases (e.g., PubMed). Cohorts from 30 studies, comprising approximately 2,500 participants, were systematically reviewed. Meta-analysis was conducted on 23 studies using a random-effects model for occupational and recreational noise exposure. Analysis showed a significant positive association between occupational noise and hearing thresholds, with medium effect sizes at 9 and 11.2 kHz and large effect sizes at 10, 12, 14, and 16 kHz. However, the association with recreational noise was less consistent, with significant effects only at 12, 12.5, and 16 kHz. Egger's test indicated some publication bias, specifically at 10 kHz. Findings suggest thresholds above 8 kHz may indicate early noise exposure effects, even when lower-frequency (≤8 kHz) thresholds remain normal. Longitudinal studies incorporating noise dosimetry are crucial to establish causality and further support the clinical utility of extended high-frequency testing.
Trends in HearingAUDIOLOGY & SPEECH-LANGUAGE PATHOLOGYOTORH-OTORHINOLARYNGOLOGY
CiteScore
4.50
自引率
11.10%
发文量
44
审稿时长
12 weeks
期刊介绍:
Trends in Hearing is an open access journal completely dedicated to publishing original research and reviews focusing on human hearing, hearing loss, hearing aids, auditory implants, and aural rehabilitation. Under its former name, Trends in Amplification, the journal established itself as a forum for concise explorations of all areas of translational hearing research by leaders in the field. Trends in Hearing has now expanded its focus to include original research articles, with the goal of becoming the premier venue for research related to human hearing and hearing loss.