{"title":"小鼠血清中多不饱和脂肪酸水平与18β-甘草次酸的抗抑郁作用有关。","authors":"Wanzhao Ding, Maohua Yao, Xiaoling Liang, Winghei Wong, Wei Yao, Ji-Chun Zhang","doi":"10.1007/s00213-025-06813-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale: </strong>18β-Glycyrrhetinic acid (18β-GA) exhibits antidepressant-like effects in mice, but the underlying mechanisms remain unclear.</p><p><strong>Objective: </strong>This study aimed to explore the role of serum polyunsaturated fatty acids in the antidepressant-like effects of 18β-GA.</p><p><strong>Results: </strong>18β-GA exerted antidepressant-like effects in mice susceptible to chronic social defeat stress (CSDS). These effects were associated with increased serum levels of docosahexaenoic acid (DHA), neuroprotectin D1 (NPD1), and N-docosahexaenoylethanolamide (DEA), alongside decreased levels of 14,15-dihydroxyeicosatrienoic acid (DHET). Additionally, 18β-GA restored the suppressed brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway and reduced the elevated pro-inflammatory cytokine levels in CSDS-susceptible mice.</p><p><strong>Conclusions: </strong>This study demonstrates that the antidepressant-like effects of 18β-GA in CSDS-susceptible mice are closely associated with DHA and its metabolites.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The serum levels of polyunsaturated fatty acids contribute to the antidepressant-like effects of 18β-Glycyrrhetinic acid in mice.\",\"authors\":\"Wanzhao Ding, Maohua Yao, Xiaoling Liang, Winghei Wong, Wei Yao, Ji-Chun Zhang\",\"doi\":\"10.1007/s00213-025-06813-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>18β-Glycyrrhetinic acid (18β-GA) exhibits antidepressant-like effects in mice, but the underlying mechanisms remain unclear.</p><p><strong>Objective: </strong>This study aimed to explore the role of serum polyunsaturated fatty acids in the antidepressant-like effects of 18β-GA.</p><p><strong>Results: </strong>18β-GA exerted antidepressant-like effects in mice susceptible to chronic social defeat stress (CSDS). These effects were associated with increased serum levels of docosahexaenoic acid (DHA), neuroprotectin D1 (NPD1), and N-docosahexaenoylethanolamide (DEA), alongside decreased levels of 14,15-dihydroxyeicosatrienoic acid (DHET). Additionally, 18β-GA restored the suppressed brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway and reduced the elevated pro-inflammatory cytokine levels in CSDS-susceptible mice.</p><p><strong>Conclusions: </strong>This study demonstrates that the antidepressant-like effects of 18β-GA in CSDS-susceptible mice are closely associated with DHA and its metabolites.</p>\",\"PeriodicalId\":20783,\"journal\":{\"name\":\"Psychopharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00213-025-06813-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00213-025-06813-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The serum levels of polyunsaturated fatty acids contribute to the antidepressant-like effects of 18β-Glycyrrhetinic acid in mice.
Rationale: 18β-Glycyrrhetinic acid (18β-GA) exhibits antidepressant-like effects in mice, but the underlying mechanisms remain unclear.
Objective: This study aimed to explore the role of serum polyunsaturated fatty acids in the antidepressant-like effects of 18β-GA.
Results: 18β-GA exerted antidepressant-like effects in mice susceptible to chronic social defeat stress (CSDS). These effects were associated with increased serum levels of docosahexaenoic acid (DHA), neuroprotectin D1 (NPD1), and N-docosahexaenoylethanolamide (DEA), alongside decreased levels of 14,15-dihydroxyeicosatrienoic acid (DHET). Additionally, 18β-GA restored the suppressed brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway and reduced the elevated pro-inflammatory cytokine levels in CSDS-susceptible mice.
Conclusions: This study demonstrates that the antidepressant-like effects of 18β-GA in CSDS-susceptible mice are closely associated with DHA and its metabolites.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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