锌在精神病中的作用（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI:10.3892/mmr.2025.13566

Christos Theleritis, Marina Demetriou, Maria-Ioanna Stefanou, Evangelos Alevyzakis, Michael Makris, Vassilios Zoumpourlis, Melpomeni Peppa, Nikolaos Smyrnis, Demetrios A Spandidos, Emmanouil Rizos

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引用次数: 0

摘要

锌（Zn）可能与精神分裂症（SCH）有关，因为其体内平衡的改变可导致谷氨酸能神经传递异常、炎症、神经变性和自身免疫异常。有研究表明，许多SCH患者可以从单独使用Zn或与维生素C、E和B6一起使用Zn中获益，并且在妊娠期产前补充Zn可以减轻脂多糖诱导的大鼠母体免疫激活模型。本综述的目的是总结锌平衡失调对精神病患者的各种影响，并阐明他们可以从锌补充中获益的方式。

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Zinc in psychosis (Review).

Zinc (Zn) may be associated with schizophrenia (SCH), since its altered homeostasis can contribute to abnormal glutamatergic neurotransmission, inflammation, neurodegeneration and autoimmune abnormalities. It has been proposed that a number of patients with SCH could benefit from the use of Zn, either on its own or along with vitamins C, E and B6, and prenatal supplementation of Zn during the gestation period can mitigate the lipopolysaccharide‑induced rat model of maternal immune activation. The aim of the present review was to summarize the various effects of Zn dyshomeostasis on patients with psychosis and to clarify in what ways they could benefit from Zn supplementation.

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来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.