{"title":"本文研究了黄杨（dasymaschalon filipes, ridl.）茎、枝次生代谢产物。以及它们的生物活动。","authors":"Tanapol Bunpan, Phansuang Udomputtimekakul, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Anan Athipornchai","doi":"10.1080/14786419.2025.2503016","DOIUrl":null,"url":null,"abstract":"<p><p>Investigation of the crude hexane and ethyl acetate extracts of the twigs and stems of <i>D. filipes</i> (Annonaceae) led to the discovery of five compounds: desmosdumotin D (<b>1</b>), a mixture of stigmasterol and <i>β</i>-sitosterol (<b>2</b>), unonal (<b>3</b>), isounonal (<b>4</b>), and cepharadione B (<b>5</b>). The structural elucidation of the compounds was accomplished using <sup>1</sup>H,<sup>13</sup>C, and 2D NMR techniques. The three crude extracts of <i>D. filipes</i> showed weak activity versus the HIV-1 virus. The cytotoxicity assays showed that the crude hexane extract was particularly effective against A549 cell lines, with an ED<sub>50</sub> of 15.24 mg/mL. Meanwhile, the crude ethyl acetate and methanol extracts inhibited KKU-M213 cell lines, demonstrating ED<sub>50</sub> values of 13.42 and 10.92 mg/mL, respectively. <i>D. filipes</i> is a rich source of potential compounds with anti-HIV-1RT or cytotoxicity activities. This is the first report on the phytochemistry and bioactivity study of <i>D. filipes</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Secondary metabolites from the twigs and stems of <i>dasymaschalon filipes</i> (ridl.) ban. and their biological activities.\",\"authors\":\"Tanapol Bunpan, Phansuang Udomputtimekakul, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Anan Athipornchai\",\"doi\":\"10.1080/14786419.2025.2503016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Investigation of the crude hexane and ethyl acetate extracts of the twigs and stems of <i>D. filipes</i> (Annonaceae) led to the discovery of five compounds: desmosdumotin D (<b>1</b>), a mixture of stigmasterol and <i>β</i>-sitosterol (<b>2</b>), unonal (<b>3</b>), isounonal (<b>4</b>), and cepharadione B (<b>5</b>). The structural elucidation of the compounds was accomplished using <sup>1</sup>H,<sup>13</sup>C, and 2D NMR techniques. The three crude extracts of <i>D. filipes</i> showed weak activity versus the HIV-1 virus. The cytotoxicity assays showed that the crude hexane extract was particularly effective against A549 cell lines, with an ED<sub>50</sub> of 15.24 mg/mL. Meanwhile, the crude ethyl acetate and methanol extracts inhibited KKU-M213 cell lines, demonstrating ED<sub>50</sub> values of 13.42 and 10.92 mg/mL, respectively. <i>D. filipes</i> is a rich source of potential compounds with anti-HIV-1RT or cytotoxicity activities. This is the first report on the phytochemistry and bioactivity study of <i>D. filipes</i>.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2503016\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2503016","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities.
Investigation of the crude hexane and ethyl acetate extracts of the twigs and stems of D. filipes (Annonaceae) led to the discovery of five compounds: desmosdumotin D (1), a mixture of stigmasterol and β-sitosterol (2), unonal (3), isounonal (4), and cepharadione B (5). The structural elucidation of the compounds was accomplished using 1H,13C, and 2D NMR techniques. The three crude extracts of D. filipes showed weak activity versus the HIV-1 virus. The cytotoxicity assays showed that the crude hexane extract was particularly effective against A549 cell lines, with an ED50 of 15.24 mg/mL. Meanwhile, the crude ethyl acetate and methanol extracts inhibited KKU-M213 cell lines, demonstrating ED50 values of 13.42 and 10.92 mg/mL, respectively. D. filipes is a rich source of potential compounds with anti-HIV-1RT or cytotoxicity activities. This is the first report on the phytochemistry and bioactivity study of D. filipes.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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