大戟属四种新的细胞毒性三萜。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-16 DOI:10.1080/14786419.2025.2503015

Yuan-Biao He, Yan-Ni Ma, Yu-Ping Huang, Wen-Na Li, Ting-Xiang Shi, Jing Yang, Yong Zhao

{"title":"大戟属四种新的细胞毒性三萜。","authors":"Yuan-Biao He, Yan-Ni Ma, Yu-Ping Huang, Wen-Na Li, Ting-Xiang Shi, Jing Yang, Yong Zhao","doi":"10.1080/14786419.2025.2503015","DOIUrl":null,"url":null,"abstract":"Our ongoing phytochemical investigation on Euphorbia fischeriana led to isolation of four new cytotoxic triterpenoids (1-4), along with twenty three known analogues (5-27). The new structures were characterised as fiseuphanins C-F (1-4) by NMR and HRESIMS spectroscopic experiments. Among them, isolates 8-15, 17-20, 22, and 25-27 were the first examples from E. fischeriana. Compounds 2, 11, and 13 exhibited significant cytotoxic activity against MCF-7 cell line with IC50 of 0.04, 6.30, and 2.44 µM, respectively, whereas, only compounds 6, 8, 11, and 23 exhibited weak inhibitory activity against A549 with IC50 values ranging from 36.37 to 81.49 µM.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Four new cytotoxic triterpenoids from Euphorbia fischeriana.\",\"authors\":\"Yuan-Biao He, Yan-Ni Ma, Yu-Ping Huang, Wen-Na Li, Ting-Xiang Shi, Jing Yang, Yong Zhao\",\"doi\":\"10.1080/14786419.2025.2503015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Our ongoing phytochemical investigation on Euphorbia fischeriana led to isolation of four new cytotoxic triterpenoids (1-4), along with twenty three known analogues (5-27). The new structures were characterised as fiseuphanins C-F (1-4) by NMR and HRESIMS spectroscopic experiments. Among them, isolates 8-15, 17-20, 22, and 25-27 were the first examples from E. fischeriana. Compounds 2, 11, and 13 exhibited significant cytotoxic activity against MCF-7 cell line with IC50 of 0.04, 6.30, and 2.44 µM, respectively, whereas, only compounds 6, 8, 11, and 23 exhibited weak inhibitory activity against A549 with IC50 values ranging from 36.37 to 81.49 µM.\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2503015\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2503015","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

我们对Euphorbia fischeriana进行的植物化学研究分离出了4种新的细胞毒性三萜（1-4），以及23种已知的类似物（5-27）。通过核磁共振和HRESIMS光谱实验表征了新结构为鱼euphanins C-F（1-4）。其中，分离株8-15、17-20、22和25-27为鱼氏大肠杆菌的首例。化合物2、11和13对MCF-7细胞系具有显著的细胞毒活性，IC50分别为0.04、6.30和2.44µM，而化合物6、8、11和23对A549具有较弱的抑制活性，IC50值为36.37 ~ 81.49µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Four new cytotoxic triterpenoids from Euphorbia fischeriana.

Our ongoing phytochemical investigation on Euphorbia fischeriana led to isolation of four new cytotoxic triterpenoids (1-4), along with twenty three known analogues (5-27). The new structures were characterised as fiseuphanins C-F (1-4) by NMR and HRESIMS spectroscopic experiments. Among them, isolates 8-15, 17-20, 22, and 25-27 were the first examples from E. fischeriana. Compounds 2, 11, and 13 exhibited significant cytotoxic activity against MCF-7 cell line with IC₅₀ of 0.04, 6.30, and 2.44 µM, respectively, whereas, only compounds 6, 8, 11, and 23 exhibited weak inhibitory activity against A549 with IC₅₀ values ranging from 36.37 to 81.49 µM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.