Runxin Yang, Leshi Yu, Xiaoting Xie, Gang Chen, Lu Wen
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Anti-inflammatory metabolites from the mangrove endophytic fungus Diaporthe pseudooculi HHUF 30617.
Certain mangrove endophytic fungi have unique physiological mechanisms, such as anti-inflammatory properties. A new polyketone, namely N-acetoxyethyl-3-(3,5-dimethyl-1,3-heptadienyl)-5-chloro-7-methyl-7-acetoxy-6,8-(2H,7H)-isoquinolinedione (1), and 17 known compounds (2-18) were isolated from the mangrove endophytic fungus Diaporthe pseudooculi HHUF 30617. The structure of the new compound was elucidated using nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray ionisation mass spectroscopy (HRESI-MS). The anti-inflammatory activities of the compounds were evaluated using the zebrafish migratory fluorescent cell count assay. The results suggest the potential of the above compounds for treating inflammation. These findings aid the development of natural marine products based on mangrove endophytic fungal metabolites to counter conditions such as copper toxicity.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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