病毒感染与免疫反应在面瘫发病机制中的协同作用。

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI:10.1007/s13365-025-01258-7
Aijun Wang, Wei Xie, Jian Zhang
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引用次数: 0

摘要

面瘫是指面部肌肉麻痹,通常由病毒感染引起,如单纯疱疹病毒1型(HSV-1)、带状疱疹病毒(VZV)和SARS-CoV-2。虽然在病毒性面瘫发病机制方面取得了重大进展,但病毒感染-免疫协同作用的机制尚未揭示。本文作者试图通过批判性地总结病毒感染在面瘫发病机制中如何通过免疫反应机制引起面神经炎症和损伤来填补这一空白。我们还总结了目前的治疗方式及其各自的疗效。本文设定了由HSV-1、VZV、SARS-CoV-2、HIV和EBV引起的病毒感染导致面瘫的条件,以及病毒如何感染面神经,引发免疫反应,导致神经死亡。其影响包括病毒直接侵入神经元、免疫逃避和诱导神经炎症。本文还讨论了T细胞、B细胞和先天免疫细胞在诱导或缓解该病中的主要作用。该研究强调需要了解病毒感染和面瘫免疫反应的协同作用,作为创造更有效治疗策略的基础。本文对面瘫患者的免疫反应与病毒感染的复杂相互作用进行了详细的综述,对面瘫的进一步研究和临床应用具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The synergistic role of viral infection and immune response in the pathogenesis of facial palsy.

Facial palsy refers to facial muscle paralysis and is typically brought about by viral infections, such as herpes simplex virus type 1 (HSV-1), herpes zoster virus (VZV), and SARS-CoV-2. While significant progress has been achieved in viral facial palsy pathogenesis, mechanisms of viral infection-immunity synergy are yet to be revealed. The authors of this article made an attempt to fill this gap by critically summarizing how viral infection causes inflammation and damage to the facial nerve through an immune response mechanism in the facial palsy pathogenesis. We also summarize the current treatment modalities and their respective efficacies. The article set the conditions under which viral infections caused by HSV-1, VZV, SARS-CoV-2, HIV, and EBV lead to facial paralysis and how the viruses infect the facial nerve, initiate an immune response, and cause nerve death. The impact involved direct viral invasion of neurons, immune evasion and induction of neuroinflammation. The review also discusses the primary role of T cells, B cells and innate immune cells in inducing or relieving the condition. The study emphasizes the need to understand the synergic effect of viral infection and immuneresponse of facial palsy as the foundation of the creation of more potent therapeutic strategies. The paper provides a detailed overview of complex interaction of immuneresponse and viral infection of facial palsy with significant level of importance regarding future research and clinical application.

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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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