{"title":"咀嚼和吞咽行为的年龄特异性临床和脑特征。","authors":"Chia-Shu Lin, Wei-Chieh Kao","doi":"10.1111/joor.13998","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mastication and swallowing are the fundamental processes for food intake and the primary functions of living. The clinical and neurological features associated with individual differences in masticatory performance and swallowing performance have remained unexplored.</p><p><strong>Objectives: </strong>The study focuses on the age-specific association between masticatory/swallowing performance and oral/systemic/nutritional factors and their association with functional brain connectivity.</p><p><strong>Methods: </strong>One-hundred and eighteen healthy adults (48 older age, 27 middle-aged and 43 younger age) were recruited for food-mixing and repetitive saliva swallowing tests, respectively, indexed for masticatory and swallowing performance, as well as oral, systemic and nutritional factors, including mid-upper arm and calf circumferences. Structural and resting-state (rs) functional magnetic resonance imaging was acquired. Seed-based connectivity analyses were conducted to investigate the association between swallowing performance and rs-functional connectivity (rs-FC) of the sensorimotor network.</p><p><strong>Results: </strong>(a) In contrast to mastication, individual swallowing performance was not associated with oral or systemic factors. (b) In older adults, higher mid-upper arm and calf circumferences were associated with both higher masticatory and swallowing performance (a statistically significant interaction, p = 0.018). (c) In older adults, higher swallowing performance was associated with stronger rs-FC between the cerebellum and basal ganglia (p = 0.008, corrected for small volume), whilst higher masticatory performance was associated with stronger rs-FC between the cerebellum and primary sensorimotor cortices (p = 0.045, corrected for small volume).</p><p><strong>Conclusion: </strong>Our findings reveal age-specific associations between swallowing, mastication, nutritional factors and brain functional connectivity. The findings highlight the association between the brain and individual differences in masticatory and swallowing performance.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-Specific Clinical and Brain Features of Masticatory and Swallowing Performance.\",\"authors\":\"Chia-Shu Lin, Wei-Chieh Kao\",\"doi\":\"10.1111/joor.13998\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mastication and swallowing are the fundamental processes for food intake and the primary functions of living. The clinical and neurological features associated with individual differences in masticatory performance and swallowing performance have remained unexplored.</p><p><strong>Objectives: </strong>The study focuses on the age-specific association between masticatory/swallowing performance and oral/systemic/nutritional factors and their association with functional brain connectivity.</p><p><strong>Methods: </strong>One-hundred and eighteen healthy adults (48 older age, 27 middle-aged and 43 younger age) were recruited for food-mixing and repetitive saliva swallowing tests, respectively, indexed for masticatory and swallowing performance, as well as oral, systemic and nutritional factors, including mid-upper arm and calf circumferences. Structural and resting-state (rs) functional magnetic resonance imaging was acquired. Seed-based connectivity analyses were conducted to investigate the association between swallowing performance and rs-functional connectivity (rs-FC) of the sensorimotor network.</p><p><strong>Results: </strong>(a) In contrast to mastication, individual swallowing performance was not associated with oral or systemic factors. (b) In older adults, higher mid-upper arm and calf circumferences were associated with both higher masticatory and swallowing performance (a statistically significant interaction, p = 0.018). (c) In older adults, higher swallowing performance was associated with stronger rs-FC between the cerebellum and basal ganglia (p = 0.008, corrected for small volume), whilst higher masticatory performance was associated with stronger rs-FC between the cerebellum and primary sensorimotor cortices (p = 0.045, corrected for small volume).</p><p><strong>Conclusion: </strong>Our findings reveal age-specific associations between swallowing, mastication, nutritional factors and brain functional connectivity. The findings highlight the association between the brain and individual differences in masticatory and swallowing performance.</p>\",\"PeriodicalId\":16605,\"journal\":{\"name\":\"Journal of oral rehabilitation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral rehabilitation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/joor.13998\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/joor.13998","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Age-Specific Clinical and Brain Features of Masticatory and Swallowing Performance.
Background: Mastication and swallowing are the fundamental processes for food intake and the primary functions of living. The clinical and neurological features associated with individual differences in masticatory performance and swallowing performance have remained unexplored.
Objectives: The study focuses on the age-specific association between masticatory/swallowing performance and oral/systemic/nutritional factors and their association with functional brain connectivity.
Methods: One-hundred and eighteen healthy adults (48 older age, 27 middle-aged and 43 younger age) were recruited for food-mixing and repetitive saliva swallowing tests, respectively, indexed for masticatory and swallowing performance, as well as oral, systemic and nutritional factors, including mid-upper arm and calf circumferences. Structural and resting-state (rs) functional magnetic resonance imaging was acquired. Seed-based connectivity analyses were conducted to investigate the association between swallowing performance and rs-functional connectivity (rs-FC) of the sensorimotor network.
Results: (a) In contrast to mastication, individual swallowing performance was not associated with oral or systemic factors. (b) In older adults, higher mid-upper arm and calf circumferences were associated with both higher masticatory and swallowing performance (a statistically significant interaction, p = 0.018). (c) In older adults, higher swallowing performance was associated with stronger rs-FC between the cerebellum and basal ganglia (p = 0.008, corrected for small volume), whilst higher masticatory performance was associated with stronger rs-FC between the cerebellum and primary sensorimotor cortices (p = 0.045, corrected for small volume).
Conclusion: Our findings reveal age-specific associations between swallowing, mastication, nutritional factors and brain functional connectivity. The findings highlight the association between the brain and individual differences in masticatory and swallowing performance.
期刊介绍：
Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function.
Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology.
The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.
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