Jan Saip Aunan-Diop, Ancuta Ioana Friismose, Bo Halle, Christian Bonde Pedersen, Bo Mussmann, Emi Hojo, Ziying Yin, Mathias Just Nortvig, Kerstin Lagerstrand, Frantz Rom Poulsen
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MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors.</p><p><strong>Purpose/hypothesis: </strong>To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population/subjects: </strong>Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection.</p><p><strong>Field strength/sequence: </strong>MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence.</p><p><strong>Assessment: </strong>Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median G' or |G*| values.</p><p><strong>Statistical tests: </strong>The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed-rank test evaluated ranking stability and scan-rescan CV%. Statistical significance was defined as p < 0.05.</p><p><strong>Results: </strong>The difference in CV% G' (14.89 ± 12.32) and CV% |G*| (13.88 ± 12.60) was not significant (p = 0.61). Tumor volume inversely correlated with CV% (G': β = -0.75 |G*|: β = -0.59). Tumor-EOP distance had no significant effect (G': p = 0.58, |G*|: p = 0.23). Rankings remained stable (G': p = 0.82, |G*|: p = 0.71).</p><p><strong>Data conclusion: </strong>MRE-derived parameters are repeatable in intracranial meningiomas, with G' and |G*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Repeatability of Magnetic Resonance Elastography-Derived Mechanical Parameters in Intracranial Meningiomas.\",\"authors\":\"Jan Saip Aunan-Diop, Ancuta Ioana Friismose, Bo Halle, Christian Bonde Pedersen, Bo Mussmann, Emi Hojo, Ziying Yin, Mathias Just Nortvig, Kerstin Lagerstrand, Frantz Rom Poulsen\",\"doi\":\"10.1002/jmri.29825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Magnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors.</p><p><strong>Purpose/hypothesis: </strong>To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population/subjects: </strong>Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection.</p><p><strong>Field strength/sequence: </strong>MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence.</p><p><strong>Assessment: </strong>Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. 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Larger tumors yielded more consistent estimates. 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引用次数: 0
摘要
背景：磁共振弹性成像（MRE）量化组织粘弹性，提供颅内脑膜瘤的见解。mre衍生的参数，包括存储模量（G'）和复合模量（|G*|）的大小，可能有助于神经外科手术计划，但其在脑肿瘤中的可重复性仍有待探索。目的/假设：评价脑膜瘤中G′和|G*|的可重复性，肿瘤体积和空间位置对变异性的影响，以及成对弹性图排序的稳定性。研究类型：前瞻性。人群/受试者：来自16例计划切除的脑膜瘤患者（平均年龄64±12岁，10例女性）的17对MRE扫描。场强/序列：在3t系统上使用单次自旋回波回波平面成像（SE-EPI）序列进行MRE。评估：在对比增强的t1加权图像上分割肿瘤；提取距离和体积指标。将感兴趣的区域应用于G'和|G*|弹性图。用变异系数（CV%）评价重复性。通过比较中位G′或|G*|值来评估排名稳定性。统计检验：CV%的差异采用Wilcoxon符号秩检验进行评估。线性回归评估肿瘤体积和距枕外隆突（EOP）的距离对CV%的影响。Wilcoxon sign -rank检验评估排序稳定性和扫描-扫描CV%。结果：CV% G′（14.89±12.32）和CV% |G*|（13.88±12.60）的差异无统计学意义（p = 0.61）。肿瘤体积与CV%呈负相关（G′：β = -0.75 |G*|: β = -0.59）。肿瘤- eop距离无显著影响（G′：p = 0.58, |G*|: p = 0.23）。排名保持稳定(G”:p = 0.82 * |: | G p = 0.71)。数据结论：颅内脑膜瘤中mre衍生参数可重复，G′和|G*|同样稳定。更大的肿瘤产生了更一致的估计。保留分级稳定性支持MRE在术前计划中的应用。证据等级：2。技术功效：第二阶段。
Repeatability of Magnetic Resonance Elastography-Derived Mechanical Parameters in Intracranial Meningiomas.
Background: Magnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors.
Purpose/hypothesis: To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms.
Study type: Prospective.
Population/subjects: Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection.
Field strength/sequence: MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence.
Assessment: Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median G' or |G*| values.
Statistical tests: The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed-rank test evaluated ranking stability and scan-rescan CV%. Statistical significance was defined as p < 0.05.
Results: The difference in CV% G' (14.89 ± 12.32) and CV% |G*| (13.88 ± 12.60) was not significant (p = 0.61). Tumor volume inversely correlated with CV% (G': β = -0.75 |G*|: β = -0.59). Tumor-EOP distance had no significant effect (G': p = 0.58, |G*|: p = 0.23). Rankings remained stable (G': p = 0.82, |G*|: p = 0.71).
Data conclusion: MRE-derived parameters are repeatable in intracranial meningiomas, with G' and |G*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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