膳食酚类化合物与成人代谢综合征房颤风险生物标志物之间的关系：一项纵向分析

IF 3.7 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2025-07-01 DOI:10.1016/j.tjnut.2025.05.007

Zenaida Vázquez-Ruiz , Alvaro Alonso , Ángel Alonso-Gómez , Dora Romaguera , Miguel Ángel Martínez-González , Linzi Li , Itziar Berrade , Lucas Tojal-Sierra , Marta Noris , Rosa M Lamuela-Raventós , Vicente Martín , Jordi Salas-Salvadó , Montserrat Fito , Estefanía Toledo

{"title":"膳食酚类化合物与成人代谢综合征房颤风险生物标志物之间的关系：一项纵向分析","authors":"Zenaida Vázquez-Ruiz , Alvaro Alonso , Ángel Alonso-Gómez , Dora Romaguera , Miguel Ángel Martínez-González , Linzi Li , Itziar Berrade , Lucas Tojal-Sierra , Marta Noris , Rosa M Lamuela-Raventós , Vicente Martín , Jordi Salas-Salvadó , Montserrat Fito , Estefanía Toledo","doi":"10.1016/j.tjnut.2025.05.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Phenolic compounds (PCs) may reduce the risk of cardiovascular disease due to their anti-inflammatory and antioxidant effects. Examining relationships between dietary intake of total PC and atrial fibrillation (AF) risk biomarkers in a Mediterranean population with metabolic syndrome may offer new insights about AF physiopathology.</div></div><div><h3>Objectives</h3><div>This observational study aimed to analyze the relationship between total PC intake and serum concentrations of 5 AF-related biomarkers over 5 y in 566 participants from the PREDIMED-Plus trial.</div></div><div><h3>Methods</h3><div>In participants with metabolic syndrome (mean age: 65.1 y; 40.4% women), the following blood biomarkers were measured at baseline and at 3 and 5 y: N-terminal pro–B-type natriuretic peptide (NT-proBNP; atrial stretch), high-sensitivity troponin T (hs-TnT; myocardial damage), high-sensitivity C-reactive protein (hs-CRP; inflammation), procollagen type 1 carboxy-terminal propeptide (PICP; fibrosis), and 3-nitrotyrosine (NT; oxidative stress). PC intake was assessed using a validated 143-item food frequency questionnaire and the Phenol-Explorer database. Changes in log-transformed biomarkers concentrations were evaluated with multivariable-adjusted mixed linear models. Sources of between-person variability in total PC intake were also evaluated.</div></div><div><h3>Results</h3><div>Over 5 y, participants with moderate-high baseline PC intake (quartiles 2–4) showed a 39.5% (95% CI: 27.4%, 52.6%; <em>P</em> < 0.001) increase in NT-proBNP concentrations compared to a 20.5% (95% CI: 3.4%, 40.3%; <em>P</em> = 0.03) increase in the lowest quartile (<em>P</em><sub>time × categories</sub> = 0.04). When PC intake was updated over follow-up, moderate-high intake showed a 32.2% (95% CI: 19.5%, 46.2%; <em>P</em> < 0.001) increase in NT-proBNP compared to a 27.3% (95% CI: 6.5%, 52.1%; <em>P</em> = 0.004) in the lowest quartile, (<em>P</em><sub>time × categories</sub> = 0.02). Participants with moderate-high PC intake undergoing intensive lifestyle intervention showed smaller increases in hs-TnT than those with lower intake. Chocolate was the main contributor to between-person variability in PC intake.</div></div><div><h3>Conclusions</h3><div>Our results show that higher PC intake was associated with larger increases in NT-proBNP concentrations. In participants undergoing an intensive lifestyle intervention and higher PC intake, a lower increase in hs-TnT concentrations was found. Future research is warranted to better understand the role of dietary intake of PC in AF-related pathways.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2253-2266"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations between Dietary Phenolic Compounds and Biomarkers of Atrial Fibrillation Risk in Adults with Metabolic Syndrome: A Longitudinal Analysis\",\"authors\":\"Zenaida Vázquez-Ruiz , Alvaro Alonso , Ángel Alonso-Gómez , Dora Romaguera , Miguel Ángel Martínez-González , Linzi Li , Itziar Berrade , Lucas Tojal-Sierra , Marta Noris , Rosa M Lamuela-Raventós , Vicente Martín , Jordi Salas-Salvadó , Montserrat Fito , Estefanía Toledo\",\"doi\":\"10.1016/j.tjnut.2025.05.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Phenolic compounds (PCs) may reduce the risk of cardiovascular disease due to their anti-inflammatory and antioxidant effects. Examining relationships between dietary intake of total PC and atrial fibrillation (AF) risk biomarkers in a Mediterranean population with metabolic syndrome may offer new insights about AF physiopathology.</div></div><div><h3>Objectives</h3><div>This observational study aimed to analyze the relationship between total PC intake and serum concentrations of 5 AF-related biomarkers over 5 y in 566 participants from the PREDIMED-Plus trial.</div></div><div><h3>Methods</h3><div>In participants with metabolic syndrome (mean age: 65.1 y; 40.4% women), the following blood biomarkers were measured at baseline and at 3 and 5 y: N-terminal pro–B-type natriuretic peptide (NT-proBNP; atrial stretch), high-sensitivity troponin T (hs-TnT; myocardial damage), high-sensitivity C-reactive protein (hs-CRP; inflammation), procollagen type 1 carboxy-terminal propeptide (PICP; fibrosis), and 3-nitrotyrosine (NT; oxidative stress). PC intake was assessed using a validated 143-item food frequency questionnaire and the Phenol-Explorer database. Changes in log-transformed biomarkers concentrations were evaluated with multivariable-adjusted mixed linear models. Sources of between-person variability in total PC intake were also evaluated.</div></div><div><h3>Results</h3><div>Over 5 y, participants with moderate-high baseline PC intake (quartiles 2–4) showed a 39.5% (95% CI: 27.4%, 52.6%; <em>P</em> < 0.001) increase in NT-proBNP concentrations compared to a 20.5% (95% CI: 3.4%, 40.3%; <em>P</em> = 0.03) increase in the lowest quartile (<em>P</em><sub>time × categories</sub> = 0.04). When PC intake was updated over follow-up, moderate-high intake showed a 32.2% (95% CI: 19.5%, 46.2%; <em>P</em> < 0.001) increase in NT-proBNP compared to a 27.3% (95% CI: 6.5%, 52.1%; <em>P</em> = 0.004) in the lowest quartile, (<em>P</em><sub>time × categories</sub> = 0.02). Participants with moderate-high PC intake undergoing intensive lifestyle intervention showed smaller increases in hs-TnT than those with lower intake. Chocolate was the main contributor to between-person variability in PC intake.</div></div><div><h3>Conclusions</h3><div>Our results show that higher PC intake was associated with larger increases in NT-proBNP concentrations. In participants undergoing an intensive lifestyle intervention and higher PC intake, a lower increase in hs-TnT concentrations was found. Future research is warranted to better understand the role of dietary intake of PC in AF-related pathways.</div></div>\",\"PeriodicalId\":16620,\"journal\":{\"name\":\"Journal of Nutrition\",\"volume\":\"155 7\",\"pages\":\"Pages 2253-2266\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022316625002895\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022316625002895","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

酚类化合物（PC）可能由于其抗炎和抗氧化作用而降低心血管疾病的风险。研究地中海代谢综合征人群中膳食总PC摄入量与房颤（AF）风险生物标志物之间的关系可能为房颤生理病理提供新的见解。目的：本观察性研究旨在分析来自PREDIMED-Plus试验的566名参与者5年内总PC摄入量与血清中5种af相关生物标志物水平之间的关系。方法：在代谢综合征患者（平均年龄：65.1岁，女性40.4%）中，在基线、3年和5年测量血液生物标志物：n端前b型利钠肽（NT-proBNP）（心房拉伸）、高敏肌钙蛋白T (hs-TnT)（心肌损伤）、高敏c反应蛋白（hs-CRP）（炎症）、前胶原1型羧基端前肽（PICP）（纤维化）和3-硝基酪氨酸（3- nt）（氧化应激）。使用经过验证的143项食物频率问卷和酚- explorer数据库评估PC摄入量。用多变量调整混合线性模型评估对数转换生物标志物水平的变化。还评估了个人之间PC总摄入量差异的来源。结果：5年多来，中高基线PC摄入量（四分位数2-4）的参与者显示39.5% (95%CI 27.4%;52.6%；结论：我们的研究结果表明，较高的PC摄入量与NT-proBNP浓度的较大增加有关。在接受ILI和高PC摄入量的参与者中，发现其- tnt水平的增加较低。未来的研究有必要更好地了解膳食摄入PC在af相关途径中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Associations between Dietary Phenolic Compounds and Biomarkers of Atrial Fibrillation Risk in Adults with Metabolic Syndrome: A Longitudinal Analysis

Background

Phenolic compounds (PCs) may reduce the risk of cardiovascular disease due to their anti-inflammatory and antioxidant effects. Examining relationships between dietary intake of total PC and atrial fibrillation (AF) risk biomarkers in a Mediterranean population with metabolic syndrome may offer new insights about AF physiopathology.

Objectives

This observational study aimed to analyze the relationship between total PC intake and serum concentrations of 5 AF-related biomarkers over 5 y in 566 participants from the PREDIMED-Plus trial.

Methods

In participants with metabolic syndrome (mean age: 65.1 y; 40.4% women), the following blood biomarkers were measured at baseline and at 3 and 5 y: N-terminal pro–B-type natriuretic peptide (NT-proBNP; atrial stretch), high-sensitivity troponin T (hs-TnT; myocardial damage), high-sensitivity C-reactive protein (hs-CRP; inflammation), procollagen type 1 carboxy-terminal propeptide (PICP; fibrosis), and 3-nitrotyrosine (NT; oxidative stress). PC intake was assessed using a validated 143-item food frequency questionnaire and the Phenol-Explorer database. Changes in log-transformed biomarkers concentrations were evaluated with multivariable-adjusted mixed linear models. Sources of between-person variability in total PC intake were also evaluated.

Results

Over 5 y, participants with moderate-high baseline PC intake (quartiles 2–4) showed a 39.5% (95% CI: 27.4%, 52.6%; P < 0.001) increase in NT-proBNP concentrations compared to a 20.5% (95% CI: 3.4%, 40.3%; P = 0.03) increase in the lowest quartile (P_{time × categories} = 0.04). When PC intake was updated over follow-up, moderate-high intake showed a 32.2% (95% CI: 19.5%, 46.2%; P < 0.001) increase in NT-proBNP compared to a 27.3% (95% CI: 6.5%, 52.1%; P = 0.004) in the lowest quartile, (P_{time × categories} = 0.02). Participants with moderate-high PC intake undergoing intensive lifestyle intervention showed smaller increases in hs-TnT than those with lower intake. Chocolate was the main contributor to between-person variability in PC intake.

Conclusions

Our results show that higher PC intake was associated with larger increases in NT-proBNP concentrations. In participants undergoing an intensive lifestyle intervention and higher PC intake, a lower increase in hs-TnT concentrations was found. Future research is warranted to better understand the role of dietary intake of PC in AF-related pathways.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.