{"title":"桑乙醇提取物对鱼藤酮诱导的小鼠神经变性和运动损伤的神经保护作用。","authors":"Rabia Anjum, Chand Raza, Mehwish Faheem","doi":"10.1080/10286020.2025.2501024","DOIUrl":null,"url":null,"abstract":"<p><p><i>Morus alba</i> formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of <i>Morus alba</i> (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuroprotective effects of <i>Morus alba</i> ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.\",\"authors\":\"Rabia Anjum, Chand Raza, Mehwish Faheem\",\"doi\":\"10.1080/10286020.2025.2501024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Morus alba</i> formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of <i>Morus alba</i> (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-19\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2025.2501024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2501024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Neuroprotective effects of Morus alba ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.
Morus alba formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of Morus alba (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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