门诊丁丙诺啡辅助阿片类药物戒断管理：一项初步前瞻性观察研究

IF 1.7 4区医学 Q3 PSYCHIATRY

Indian Journal of Psychiatry Pub Date : 2025-04-01 Epub Date: 2025-04-15 DOI:10.4103/indianjpsychiatry.indianjpsychiatry_1084_24

Avinash Jhajharia, Priyanka Saha, Piyali Mandal, Atul Ambekar

{"title":"门诊丁丙诺啡辅助阿片类药物戒断管理：一项初步前瞻性观察研究","authors":"Avinash Jhajharia, Priyanka Saha, Piyali Mandal, Atul Ambekar","doi":"10.4103/indianjpsychiatry.indianjpsychiatry_1084_24","DOIUrl":null,"url":null,"abstract":"Background: Indian guidelines mention the use of buprenorphine in opioid withdrawal in both outpatient and inpatient setting.Aim: This is the first study aiming at assessing the feasibility aspects of outpatient-based buprenorphine-assisted opioid withdrawal treatment for opioid dependence.Methods: In this prospective observational study, 30 men with opioid dependence, planned for outpatient-based withdrawal management, were recruited by purposive sampling and were assessed at baseline, 2, 4, and 12 weeks using validated tools. Abstinence was validated by a urine toxicology screen.Results: The median age of the sample was 24 (21.75-28.0) years. About 67% retained in treatment with a treatment perception score of 4.1 (4.0-4.4) and a significant reduction of craving and withdrawal scores. More than 80% were abstinent at 12 weeks.Conclusion: The study findings suggest that outpatient-based buprenorphine-assisted acute opioid withdrawal management is a feasible and acceptable treatment. Considering the relatively few inpatient addiction treatment settings, the findings are promising.","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"67 4","pages":"428-431"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073959/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outpatient-based buprenorphine-assisted opioid withdrawal management: A preliminary prospective observational study.\",\"authors\":\"Avinash Jhajharia, Priyanka Saha, Piyali Mandal, Atul Ambekar\",\"doi\":\"10.4103/indianjpsychiatry.indianjpsychiatry_1084_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Indian guidelines mention the use of buprenorphine in opioid withdrawal in both outpatient and inpatient setting.Aim: This is the first study aiming at assessing the feasibility aspects of outpatient-based buprenorphine-assisted opioid withdrawal treatment for opioid dependence.Methods: In this prospective observational study, 30 men with opioid dependence, planned for outpatient-based withdrawal management, were recruited by purposive sampling and were assessed at baseline, 2, 4, and 12 weeks using validated tools. Abstinence was validated by a urine toxicology screen.Results: The median age of the sample was 24 (21.75-28.0) years. About 67% retained in treatment with a treatment perception score of 4.1 (4.0-4.4) and a significant reduction of craving and withdrawal scores. More than 80% were abstinent at 12 weeks.Conclusion: The study findings suggest that outpatient-based buprenorphine-assisted acute opioid withdrawal management is a feasible and acceptable treatment. Considering the relatively few inpatient addiction treatment settings, the findings are promising.\",\"PeriodicalId\":13345,\"journal\":{\"name\":\"Indian Journal of Psychiatry\",\"volume\":\"67 4\",\"pages\":\"428-431\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073959/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_1084_24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_1084_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

背景：印度指南提到丁丙诺啡在门诊和住院戒断阿片类药物的使用。目的：这是第一项旨在评估门诊丁丙诺啡辅助阿片类药物戒断治疗阿片类药物依赖可行性的研究。方法：在这项前瞻性观察性研究中，通过目的抽样招募了30名阿片类药物依赖的男性，计划进行基于门诊的戒断管理，并使用经过验证的工具在基线、2周、4周和12周进行评估。通过尿液毒理学筛查证实了禁欲。结果：样本中位年龄为24（21.75 ~ 28.0）岁。约67%的人接受了治疗，治疗感知得分为4.1(4.0-4.4)，渴望和戒断得分显著降低。超过80%的人在12周时戒酒。结论：门诊丁丙诺啡辅助急性阿片类药物戒断管理是一种可行且可接受的治疗方法。考虑到相对较少的住院成瘾治疗设置，研究结果是有希望的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Outpatient-based buprenorphine-assisted opioid withdrawal management: A preliminary prospective observational study.

Background: Indian guidelines mention the use of buprenorphine in opioid withdrawal in both outpatient and inpatient setting.

Aim: This is the first study aiming at assessing the feasibility aspects of outpatient-based buprenorphine-assisted opioid withdrawal treatment for opioid dependence.

Methods: In this prospective observational study, 30 men with opioid dependence, planned for outpatient-based withdrawal management, were recruited by purposive sampling and were assessed at baseline, 2, 4, and 12 weeks using validated tools. Abstinence was validated by a urine toxicology screen.

Results: The median age of the sample was 24 (21.75-28.0) years. About 67% retained in treatment with a treatment perception score of 4.1 (4.0-4.4) and a significant reduction of craving and withdrawal scores. More than 80% were abstinent at 12 weeks.

Conclusion: The study findings suggest that outpatient-based buprenorphine-assisted acute opioid withdrawal management is a feasible and acceptable treatment. Considering the relatively few inpatient addiction treatment settings, the findings are promising.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Indian Journal of Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

4.40

自引率

3.20%

发文量

130

审稿时长

34 weeks

期刊介绍： The Indian Journal of Psychiatry (ISSN 0019-5545), is an official publication of the Indian Psychiatric Society. It is published Bimonthly with one additional supplement (total 5 issues). The IJP publishes original work in all the fields of psychiatry. All papers are peer-reviewed before publication. The issues are published Bimonthly. An additional supplement is also published annually. Articles can be submitted online from www.journalonweb.com . The journal provides immediate free access to all the published articles. The journal does not charge the authors for submission, processing or publication of the articles.