巨噬细胞抑制在减轻减肥手术引起的非酒精性脂肪性肝炎中的作用

IF 5 3区医学 Q1 GENETICS & HEREDITY

Genes and immunity Pub Date : 2025-05-15 DOI:10.1038/s41435-025-00334-6

Qianwen Zheng, Shizhou Deng, Xiyu Chen, Yayun Wang, Yanling Yang

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引用次数: 0

摘要

非酒精性脂肪性肝炎（NASH）的发病率在全球范围内呈上升趋势，迫切需要有效的治疗。为了了解减肥手术治疗NASH有效性背后的分子机制，我们整合了单细胞和大量RNA测序数据，以确定肝巨噬细胞极化在缓解NASH中的作用，并筛选可能的治疗药物。分析显示，减肥手术通过抑制肝脏M1巨噬细胞极化，通过12个差异表达的M1巨噬细胞相关基因缓解NASH。此外，预计有56种潜在的有效药物可用于NASH治疗。这些发现揭示了减肥手术治疗NASH的有效性，并为进一步探索潜在的候选药物提供了线索。

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Macrophage inhibition in the alleviation of nonalcoholic steatohepatitis caused by bariatric surgery.

The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, and effective treatment is urgently needed. To understand the molecular mechanisms behind the effectiveness of bariatric surgery in treating NASH, we integrated single-cell and bulk RNA sequencing data to identify the role of liver macrophage polarization in alleviating NASH and screen possible drugs for treatment. Analysis revealed that bariatric surgery alleviates NASH by inhibiting liver M1 macrophage polarization with 12 differentially expressed M1 macrophage-related genes. Additionally, 56 potentially effective drugs were predicted for NASH treatment. These findings shed light on the effectiveness of bariatric surgery in treating NASH and offer potential drug candidates for further exploration.

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来源期刊

Genes and immunity 医学-免疫学

CiteScore

8.90

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.