小叶Malva parviflora叶片对尼罗罗非鱼Polyram DF(干流)毒性的缓解潜力:免疫/凋亡标志物,生化,抗氧化和组织病理学见解。

IF 2.5 3区 农林科学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Elsayed M Younis, Rowida E Ibrahim, Abdelwahab A Abdelwarith, Engy Mohamed Mohamed Yassin, Kholoud A Alhallag, Mohammed S Sobh, Mohamed Shaalan, Tarek Khamis, Afaf N Abdel Rahman
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引用次数: 0

摘要

在全球范围内,不当使用农药,特别是杀菌剂对水体的污染危及水生生物,阻碍了可持续水产养殖。探索创新的策略来缓解这一难题,既环保又具有成本效益,这是必不可少的。本文评估了埃及锦葵(Malva parviflora)叶(EML)作为粉末形式在尼罗罗非鱼(Oreochromis niloticus)中减轻metiram (MET)暴露的毒理学影响的潜力。该研究的特点是生长、生理、免疫/抗氧化反应、脾细胞因子表达和组织病理学概念。据此,鱼(N = 200;(32.80±0.92 g),最终分为4组,每组5组(对照组、EML、MET、EML + MET),试验期63 d。对照组和EML组饲喂基础饲粮,分别添加0和15 g EML/kg饲粮,不添加MET。MET组和EML + MET组分别饲喂与对照组和EML组相同的饲粮,均添加0.38 mg/L MET。研究结果突出了显著的(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitigating potential of Malva parviflora leaves against Polyram DF (dry flowable) toxicity in Nile tilapia: immune/apoptotic markers, biochemical, antioxidant, and histopathological insights.

Globally, the contamination of aquatic bodies by improper application of pesticides, particularly fungicides, endangered aquatic life and hampered sustainable aquaculture. Exploring innovative strategies to mitigate this difficult issue as eco-friendly and cost-effective is indispensable. Herein, the potential of dietary Egyptian mallow (Malva parviflora) leaves (EML) as a powder form to mitigate the toxicological implications of metiram (MET) exposure in Oreochromis niloticus (Nile tilapia) was assessed in this attempt. The investigation featured growth, physiological, immune/antioxidant responses, splenic cytokines expression, and histopathological concepts. In light of this, fish (N = 200; 32.80 ± 0.92 g) were eventually assigned into four groups with five sets (control, EML, MET, and EML + MET) for 63 days. The control and EML groups were given basal diets that had 0 and 15 g EML/kg diet, respectively, without MET exposure. Furthermore, MET and EML + MET groups were received the identical diets as control and EML groups, respectively, and exposed to 0.38 mg/L MET. The findings highlighted a significant (P < 0.001) growth retardation (declining in weight gain and specific growth rate) and higher fish mortality (32%) by MET exposure. Also, immune impairment (lowered immunoglobulin M and complement 3) and oxidative damage (higher malondialdehyde and declined catalase and superoxide dismutase) were the outcomes of MET toxicity. In addition, the biochemical biomarkers showed substantial disruptions (P < 0.001) in the MET group, where creatinine, aspartate aminotransferase, and alanine aminotransferase increased. Splenic expression of immune-relevant cytokines (interleukin-10 and interferon-gamma 1) was downregulated with upregulation of apoptosis (cysteine-aspartic acid protease-3) linked gene by MET toxicity (P < 0.001). Histologically, MET significantly provoked a diverse range of aberrations in the spleen, kidney, and liver tissues. Remarkably, feeding the EML diet to the MET group decreased fish mortality (14%) and refined all metrics, while retaining the histological integrity of tissues. The conclusion of this viewpoint recommends using dietary EML (15 g/kg) to diminish the deleterious effects of MET in toxicity in Nile tilapia to sustain aquaculture.

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来源期刊
Fish Physiology and Biochemistry
Fish Physiology and Biochemistry 农林科学-生化与分子生物学
CiteScore
5.60
自引率
6.90%
发文量
106
审稿时长
4 months
期刊介绍: Fish Physiology and Biochemistry is an international journal publishing original research papers in all aspects of the physiology and biochemistry of fishes. Coverage includes experimental work in such topics as biochemistry of organisms, organs, tissues and cells; structure of organs, tissues, cells and organelles related to their function; nutritional, osmotic, ionic, respiratory and excretory homeostasis; nerve and muscle physiology; endocrinology; reproductive physiology; energetics; biochemical and physiological effects of toxicants; molecular biology and biotechnology and more.
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