猕猴桃树皮的细胞毒性类柠檬素。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-16 DOI:10.1080/10286020.2025.2501020

Xue-Hua Li, Jian-Jun Lei, Yang Chi, Xin-Pei Wang, Yu-Wei Xiao, Qian Sun, He Zhang

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引用次数: 0

摘要

一项对siamensis树皮90%甲醇提取物的植物化学研究提供了三种未描述的柠檬素，siamensis A- c（1-3）。新化合物的结构通过NMR、IR、UV和MS等光谱分析得到了证实。体外对5种胰腺细胞株进行了细胞毒活性测定。结果表明，类柠檬素3对肿瘤细胞系均表现出一定的细胞毒活性，IC50值均小于20 μM。

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Cytotoxic limonoids from the barks of Chisocheton siamensis.

A phytochemical study of 90% methanol extract of the barks of Chisocheton siamensis afforded three undescribed limonoids, siamensisines A-C (1-3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated limonoids were tested in vitro for cytotoxic activities against 5 pancreatic cell lines. As a result, limonoid 3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC₅₀ values less than 20 μM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.