呼吸窘迫综合征和支气管肺发育不良早产儿俱乐部细胞分泌蛋白（CC16）多态性

IF 3 3区医学 Q1 PEDIATRICS

European Journal of Pediatrics Pub Date : 2025-05-15 DOI:10.1007/s00431-025-06169-7

Dimitrios Rallis, Petros Bozidis, Marianthi Sotiropoulou, Georgia Ragia, Maria Baltogianni, Niki Dermitzaki, Eleni Maragoudaki, Vangelis G Manolopoulos, Konstantina Gartzonika, Katerina Antoniou, Vasileios Giapros

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A significant association of increased risk of RDS was detected for the homozygous GG rs4963506 variant (OR 3.03, 95%CI 1.36-6.75, p = 0.021), and the homozygous GG rs12270961 variant (OR 2.88, 95%CI 1.31-6.28, p = 0.024), but not for the homozygous GG rs3741240 variant, after adjusting for gestational age, mode of delivery, and antenatal administration of steroids. The homozygous GG rs4963506 variant was also associated with higher serum levels of CC16 compared to the GA/AA rs4963506 variants, on the first postnatal day. No associations between BPD and the genotype frequencies of any polymorphisms were detected.Conclusion: In preterm neonates, the homozygous GG rs4963506 and rs12270961 variants were both substantially associated with a higher risk of RDS. 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引用次数: 0

摘要

目的探讨早产儿俱乐部细胞分泌蛋白（CC16）多态性基因型频率及其与呼吸窘迫综合征（RDS）、支气管肺发育不良（BPD）的关系。对187例胎龄≤34周的早产儿进行前瞻性队列研究。检测rs4963506、rs12270961和rs3741240 CC16多态性基因型频率，比较新生儿与非RDS、BPD与非BPD的CC16多态性。在出生后第1天和第14天测定血清CC16。在调整胎龄、分娩方式和产前类固醇给药后，检测到纯合子GG rs496506变异（OR 3.03, 95%CI 1.36-6.75, p = 0.021）和纯合子GG rs12270961变异（OR 2.88, 95%CI 1.31-6.28, p = 0.024）与RDS风险增加有显著相关性，而纯合子GG rs3741240变异则无显著相关性。与GA/AA rs4963506变体相比，纯合子GG rs4963506变体在出生后第一天也与较高的血清CC16水平相关。未检测到BPD与任何多态性基因型频率之间的关联。结论：在早产儿中，纯合子GG rs4963506和rs12270961变异均与RDS的高风险显著相关。需要进一步的研究来验证我们的发现，并探索CC16多态性检测在新生儿呼吸系统疾病风险中的潜在作用。∙血清俱乐部细胞分泌蛋白（CC16）反映肺的发育成熟和组织损伤的愈合机制。∙CC16多态性与儿童肺功能的关联并不一致。∙没有证据表明CC16多态性与新生儿呼吸道疾病之间存在关联。∙纯合子GG rs4963506和GG rs12270961变异与新生儿呼吸窘迫风险增加相关。∙纯合子GG rs4963506变异也与产后第一天较高的血清CC16水平相关。∙未检测到BPD与任何多态性基因型频率之间的相关性。

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Club cell secretory protein (CC16) polymorphisms in preterm neonates with respiratory distress syndrome and bronchopulmonary dysplasia.

To investigate the genotype frequencies of club cell secretory protein (CC16) polymorphisms in preterm neonates and explore their association with respiratory distress syndrome (RDS), and bronchopulmonary dysplasia (BPD). A prospective cohort study was conducted including 187 preterm neonates of ≤ 34 weeks of gestational age. Genotype frequencies of rs4963506, rs12270961, and rs3741240 CC16 polymorphisms were detected, comparing the CC16 polymorphisms between neonates with versus without RDS, and with versus without BPD. Serum CC16 was measured, when available, on the first and fourteenth postnatal days. A significant association of increased risk of RDS was detected for the homozygous GG rs4963506 variant (OR 3.03, 95%CI 1.36-6.75, p = 0.021), and the homozygous GG rs12270961 variant (OR 2.88, 95%CI 1.31-6.28, p = 0.024), but not for the homozygous GG rs3741240 variant, after adjusting for gestational age, mode of delivery, and antenatal administration of steroids. The homozygous GG rs4963506 variant was also associated with higher serum levels of CC16 compared to the GA/AA rs4963506 variants, on the first postnatal day. No associations between BPD and the genotype frequencies of any polymorphisms were detected.

Conclusion: In preterm neonates, the homozygous GG rs4963506 and rs12270961 variants were both substantially associated with a higher risk of RDS. Further studies are warranted to validate our findings and explore the potential role of CC16 polymorphism detection in neonates at risk of respiratory morbidities.

What is known: ∙ Serum club cell secretory protein (CC16) reflects the lung's developmental maturation and healing mechanisms for tissue damage. ∙ The CC16 polymorphisms have been inconsistently associated with lung function in children. ∙ No evidence exists regarding the association between CC16 polymorphisms and respiratory morbidity in neonates.

What is new: ∙ Homozygous GG rs4963506 and GG rs12270961variants were associated with increased risk of respiratory distress in neonates. ∙ Homozygous GG rs4963506 variant was also associated with higher serum levels of CC16 on the first postnatal day. ∙ No associations between BPD and the genotype frequencies of any polymorphisms were detected.

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来源期刊

European Journal of Pediatrics 医学-小儿科

CiteScore

5.90

自引率

2.80%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The European Journal of Pediatrics (EJPE) is a leading peer-reviewed medical journal which covers the entire field of pediatrics. The editors encourage authors to submit original articles, reviews, short communications, and correspondence on all relevant themes and topics. EJPE is particularly committed to the publication of articles on important new clinical research that will have an immediate impact on clinical pediatric practice. The editorial office very much welcomes ideas for publications, whether individual articles or article series, that fit this goal and is always willing to address inquiries from authors regarding potential submissions. Invited review articles on clinical pediatrics that provide comprehensive coverage of a subject of importance are also regularly commissioned. The short publication time reflects both the commitment of the editors and publishers and their passion for new developments in the field of pediatrics. EJPE is active on social media (@EurJPediatrics) and we invite you to participate. EJPE is the official journal of the European Academy of Paediatrics (EAP) and publishes guidelines and statements in cooperation with the EAP.