Elham Sadeghi, Anne Schulman, Sharat Chandra Vupparaboina, Sumit Randhir Singh, Nasiq Hasan, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Andrew W Eller, Jay Chhablani
{"title":"视网膜-脉络膜厚度和血管指标与黄斑变性严重程度的相关性研究。","authors":"Elham Sadeghi, Anne Schulman, Sharat Chandra Vupparaboina, Sumit Randhir Singh, Nasiq Hasan, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Andrew W Eller, Jay Chhablani","doi":"10.1038/s41433-025-03847-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To assess retinal vascular perfusion and choroidal vascularity biomarkers correlated with drusen volume and severity of age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>Patients underwent swept-source optical coherence tomography angiography (SS-OCTA) (PlexElite-9000). Eyes with geographic atrophy or neovascular AMD were excluded. Retinal thickness, retinal perfusion including superficial (SCP) and deep capillary plexuses (DCP), foveal avascular zone (FAZ), drusen volume, choroidal thickness (ChT) and choroidal vascularity index (CVI) were assessed through the Advanced Research and Innovation Network. Linear mixed model and Spearman test were used for statistical analysis.</p><p><strong>Results: </strong>We assessed 81 eyes from 57 subjects (34 early-stage, 47 intermediate-stage AMD). The mean age was 74.95 ± 8.79 years. The mean LogMar visual acuity (VA) was 0.16 ± 0.18 (early-stage: 0.12 ± 0.17, intermediate-stage: 0.19 ± 0.18, P = 0.122). Between early and intermediate AMD, no significant differences were seen in SCP and DCP vascular perfusion (P = 0.368, 0.859, respectively), FAZ (p = 0.836) and retinal thickness within the 6-mm area (P = 0.680). Drusen volume showed a significant difference (early-stage: 0.0706 ± 0.1272, intermediate-stage: 0.2102 ± 0.2211mm<sup>3</sup>, P < 0.01). Intermediate-stage AMD had significantly lower mean ChT (266.40 ± 115.55 vs. 204.97 ± 70.69 µm, P = 0.038) and CVI (0.605 ± 0.021 vs. 0.591 ± 0.015, P = 0.004) within the 5-mm area. Drusen volume was negatively correlated with ChT (r = -0.198, P = 0.017) and CVI (r = -0.209, P = 0.029). No significant correlation was found between drusen volume and VA (r = 0.051, P = 0.143), retinal thickness (-0.03, P = 0.393), FAZ (r = -0.023, P = 0.150), SCP (r = -0.011, P = 0.307), and DCP (r = -0.022, P = 0.190).</p><p><strong>Conclusion: </strong>Drusen volume, a key AMD severity marker, correlates more strongly with choroidal parameters like ChT and CVI than retinal thickness and perfusion. It may serve as a biomarker for dry AMD severity, with choroidal biomarkers showing earlier disease changes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.\",\"authors\":\"Elham Sadeghi, Anne Schulman, Sharat Chandra Vupparaboina, Sumit Randhir Singh, Nasiq Hasan, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Andrew W Eller, Jay Chhablani\",\"doi\":\"10.1038/s41433-025-03847-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To assess retinal vascular perfusion and choroidal vascularity biomarkers correlated with drusen volume and severity of age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>Patients underwent swept-source optical coherence tomography angiography (SS-OCTA) (PlexElite-9000). Eyes with geographic atrophy or neovascular AMD were excluded. Retinal thickness, retinal perfusion including superficial (SCP) and deep capillary plexuses (DCP), foveal avascular zone (FAZ), drusen volume, choroidal thickness (ChT) and choroidal vascularity index (CVI) were assessed through the Advanced Research and Innovation Network. Linear mixed model and Spearman test were used for statistical analysis.</p><p><strong>Results: </strong>We assessed 81 eyes from 57 subjects (34 early-stage, 47 intermediate-stage AMD). The mean age was 74.95 ± 8.79 years. The mean LogMar visual acuity (VA) was 0.16 ± 0.18 (early-stage: 0.12 ± 0.17, intermediate-stage: 0.19 ± 0.18, P = 0.122). Between early and intermediate AMD, no significant differences were seen in SCP and DCP vascular perfusion (P = 0.368, 0.859, respectively), FAZ (p = 0.836) and retinal thickness within the 6-mm area (P = 0.680). Drusen volume showed a significant difference (early-stage: 0.0706 ± 0.1272, intermediate-stage: 0.2102 ± 0.2211mm<sup>3</sup>, P < 0.01). Intermediate-stage AMD had significantly lower mean ChT (266.40 ± 115.55 vs. 204.97 ± 70.69 µm, P = 0.038) and CVI (0.605 ± 0.021 vs. 0.591 ± 0.015, P = 0.004) within the 5-mm area. Drusen volume was negatively correlated with ChT (r = -0.198, P = 0.017) and CVI (r = -0.209, P = 0.029). No significant correlation was found between drusen volume and VA (r = 0.051, P = 0.143), retinal thickness (-0.03, P = 0.393), FAZ (r = -0.023, P = 0.150), SCP (r = -0.011, P = 0.307), and DCP (r = -0.022, P = 0.190).</p><p><strong>Conclusion: </strong>Drusen volume, a key AMD severity marker, correlates more strongly with choroidal parameters like ChT and CVI than retinal thickness and perfusion. It may serve as a biomarker for dry AMD severity, with choroidal biomarkers showing earlier disease changes.</p>\",\"PeriodicalId\":12125,\"journal\":{\"name\":\"Eye\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eye\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41433-025-03847-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41433-025-03847-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.
Purpose: To assess retinal vascular perfusion and choroidal vascularity biomarkers correlated with drusen volume and severity of age-related macular degeneration (AMD).
Methods: Patients underwent swept-source optical coherence tomography angiography (SS-OCTA) (PlexElite-9000). Eyes with geographic atrophy or neovascular AMD were excluded. Retinal thickness, retinal perfusion including superficial (SCP) and deep capillary plexuses (DCP), foveal avascular zone (FAZ), drusen volume, choroidal thickness (ChT) and choroidal vascularity index (CVI) were assessed through the Advanced Research and Innovation Network. Linear mixed model and Spearman test were used for statistical analysis.
Results: We assessed 81 eyes from 57 subjects (34 early-stage, 47 intermediate-stage AMD). The mean age was 74.95 ± 8.79 years. The mean LogMar visual acuity (VA) was 0.16 ± 0.18 (early-stage: 0.12 ± 0.17, intermediate-stage: 0.19 ± 0.18, P = 0.122). Between early and intermediate AMD, no significant differences were seen in SCP and DCP vascular perfusion (P = 0.368, 0.859, respectively), FAZ (p = 0.836) and retinal thickness within the 6-mm area (P = 0.680). Drusen volume showed a significant difference (early-stage: 0.0706 ± 0.1272, intermediate-stage: 0.2102 ± 0.2211mm3, P < 0.01). Intermediate-stage AMD had significantly lower mean ChT (266.40 ± 115.55 vs. 204.97 ± 70.69 µm, P = 0.038) and CVI (0.605 ± 0.021 vs. 0.591 ± 0.015, P = 0.004) within the 5-mm area. Drusen volume was negatively correlated with ChT (r = -0.198, P = 0.017) and CVI (r = -0.209, P = 0.029). No significant correlation was found between drusen volume and VA (r = 0.051, P = 0.143), retinal thickness (-0.03, P = 0.393), FAZ (r = -0.023, P = 0.150), SCP (r = -0.011, P = 0.307), and DCP (r = -0.022, P = 0.190).
Conclusion: Drusen volume, a key AMD severity marker, correlates more strongly with choroidal parameters like ChT and CVI than retinal thickness and perfusion. It may serve as a biomarker for dry AMD severity, with choroidal biomarkers showing earlier disease changes.
期刊介绍：
Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists.
Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.
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