脂质纳米载体在肿瘤靶向治疗中的研究进展及展望

IF 2.3 4区 医学 Q3 ONCOLOGY
Suraj Mandal
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引用次数: 0

摘要

导读:靶向癌症治疗通过提高治疗精度和减少意外副作用的发生,显著改变了肿瘤学领域。由于其生物相容性、柔韧性和功能化能力,基于脂质的纳米载体已经成为递送化疗药物的可行平台。目的和目的:本研究的目的是探讨基于脂质纳米载体在靶向癌症治疗领域的现状和未来前景。目标包括检查脂质纳米载体发展的最新进展,评估其在临床应用中的有效性,并确定增强和新颖的机会。材料和方法:进行了广泛的文献分析,包括检查目前在癌症治疗中使用脂基纳米载体的研究。对有关纳米载体配方、靶向机制、治疗结果和临床试验的数据进行了分析,以发现趋势和新技术。结果:基于脂质的纳米载体,包括脂质体、固体脂质纳米颗粒和纳米乳,最近的进展显示出增强药物传递和降低毒性。靶向方法,如利用配体-受体相互作用和刺激反应系统,显著提高了治疗方法的准确性和有效性。结论:脂质纳米载体在推进肿瘤靶向治疗方面具有广阔的应用前景。尽管已经取得了重大进展,但仍有必要继续开发配方流程和靶向策略,以克服现有的制约因素并改善临床结果。跨多个研究领域的持续合作对于有效地将这些纳米技术从实验室应用到医疗保健的实际应用至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and Future Prospects of Lipid-Based Nanocarriers in Targeted Cancer Therapy: A Comprehensive Review.

Introduction: Targeted cancer therapy has significantly transformed the field of oncology by improving treatment precision and reducing the occurrence of unintended side effects. Lipid-based nanocarriers have become a viable platform for delivering chemothera-peutic drugs due to their biocompatibility, flexibility, and ability to be functionalised.

Aim and objectives: The objective of this research is to investigate the present tactics and future prospects of lipid-based nanocarriers in the field of targeted cancer treatment. The goals include the examination of recent progress in the development of lipid nanocarriers, evaluating their effectiveness in clinical uses, and pinpointing opportunities for enhancement and novelty.

Material and method: An extensive literature analysis was performed, including examining current research on the use of lipid-based nanocarriers in cancer treatment. An analysis was conducted on data pertaining to nanocarrier formulations, targeting mechanisms, treatment results, and clinical trials in order to detect trends and new technologies.

Results: Recent progress in lipid-based nanocarriers, including liposomes, solid lipid nano-particles, and nanoemulsions, has shown enhanced drug delivery and decreased toxicity. Targeting methods, such as the utilisation of ligand-receptor interactions and stimuli-responsive systems, have significantly improved the precision and effectiveness of therapeu-tics.

Conclusion: Lipid-based nanocarriers have great potential for advancing targeted cancer treatment in the future. Although there has been significant progress, it is essential to con-tinue developing formulation processes and targeting tactics to overcome existing con-straints and improve clinical results. Ongoing cooperation across several fields of study will be crucial in effectively applying these nanotechnologies from the laboratory to practical use in healthcare.

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来源期刊
Current cancer drug targets
Current cancer drug targets 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
105
审稿时长
1 months
期刊介绍: Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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