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引用次数: 0
摘要
背景：癌症是一个主要的公共卫生问题，手术、化疗和放疗等传统治疗方法存在一些缺点，包括化疗耐药、毒性和癌症患者家庭的经济负担。因此，发现新的药物或天然药物来减少这些副作用是至关重要的。一系列的研究表明，蒽醌是一种很有前途的辅助剂，可以提高标准癌症治疗的有效性。目的：综述蒽醌类药物的抗癌潜力及其在标准化疗中的作用。方法：检索PubMed、Scopus、谷歌Scholar和Web of Science等免费数据库，检索有关蒽醌类药物及其作为标准化疗药物辅助使用的最新相关信息。结果：本文综述了近年来蒽醌类佐剂在化疗中的应用进展。进一步阐述了蒽醌类药物对耐药癌细胞化学致敏的作用机制。结论：这篇综述提供了关于新出现的作用和它们作为佐剂在提高常规癌症治疗效果方面的潜力的最新信息。
Synergistic Interactions of Anthraquinones with Conventional Cancer Therapies.
Background: Cancer is a major public health concern, and conventional treatments like surgery, chemotherapy, and radiotherapy are associated with several disadvantages, including chemoresistance, toxicity, and economic burden to the family of cancer patients. Thus, discovery of novel agents of natural agents to reduce these side effects is crucial. A series of studies have shown anthraquinones as a promising adjuvant in enhancing the effectiveness of standard cancer therapies.
Objective: This review explores the anticancer potential of anthraquinones and their role in enhancing standard chemotherapy.
Methodology: Various freely available databases, including PubMed, Scopus, Google Scholar and Web of Science were searched for updated and relevant information on anthraquinones and their use as an adjuvant with standard chemotherapeutic agents.
Results: In this article, we looked at the recent developments in the utilization of anthraquinones as adjuvants in chemotherapy. Further, we have elaborated the mechanism of action that anthraquinones target to chemosensitize the drug-resistant cancer cells.
Conclusion: This review provides updated information on emerging role and their potential to be utilized as adjuvants in augmenting the efficacy of conventional cancer therapies.
期刊介绍：
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
Target identification and validation
Assay design, development, miniaturization and comparison
High throughput/high content/in silico screening and associated technologies
Label-free detection technologies and applications
Stem cell technologies
Biomarkers
ADMET/PK/PD methodologies and screening
Probe discovery and development, hit to lead optimization
Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
Chemical library design and chemical diversity
Chemo/bio-informatics, data mining
Compound management
Pharmacognosy
Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
Natural Product Analytical Studies
Bipharmaceutical studies of Natural products
Drug repurposing
Data management and statistical analysis
Laboratory automation, robotics, microfluidics, signal detection technologies
Current & Future Institutional Research Profile
Technology transfer, legal and licensing issues
Patents.
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